Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

LLGL2

  • Official Full Name

    lethal giant larvae homolog 2

  • Overview

    The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the proteins ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    LLGL2; lethal giant larvae homolog 2 (Drosophila); lethal giant larvae (Drosophila) homolog 2; lethal(2) giant larvae protein homolog 2; HGL; human giant larvae homolog; LGL2;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LLGL2-29145TH Recombinant Human LLGL2 Wheat Germ N/A 99 amino acids
Human LLGL2-4720HCL Recombinant Human LLGL2 293 Cell Lysate HEK293 N/A
Mouse Llgl2-3795M Recombinant Mouse Llgl2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish LLGL2-11861Z Recombinant Zebrafish LLGL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LLGL2 Related Articles

LLGL2 involved in several pathways and played different roles in them. We selected most pathways LLGL2 participated on our site, such as Hippo signaling pathway, Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LLGL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayCTNNA2;CTNNA3;YWHAG;Fzd4;YWHAB;GDF7;FZD2;SMAD3;PPP2R2C
Tight junctionPRKCG;AKT3A;CRB3;ACTB;RHOAC;ZAK;MAGI2;PPP2CA;SHROOM1

LLGL2 has several biochemical functions, for example, GTPase activator activity, PDZ domain binding, Rab GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LLGL2 itself. We selected most functions LLGL2 had, and list some proteins which have the same functions with LLGL2. You can find most of the proteins on our site.

Function Related Protein
GTPase activator activitySTXBP5L;PREX2;ASAP2A;ALDH1A2;FAM13A;OPHN1;THY1;RACGAP1;RASAL1
PDZ domain bindingPTEN;GRM7;SLC9A3R2;SSTR2;LRP2;LIN7B;CIT;FZD7;GNG5
Rab GTPase bindingBICD1;RABGAP1L;CCDC64;NGFR;MICALL1;HPS6;CCDC64B;RAB11FIP4B;SGSM2
protein bindingLMLN;RNF10;DYRK1A;NAT8B;TNNI2;RSPH1;SSX5;FBXO4;GRIFIN
NOT syntaxin bindingC2CD4A;LLGL2;LLGL1;C2CD4B;TC2N

LLGL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LLGL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LLGL2.

PRKCI; PARD6B; PARD6A; ssrna_uc; ATF2; RBBP6

Kohn, KW; Zeeberg, BM; et al. Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype. PLOS ONE 9:-(2014).
Linch, M; Sanz-Garcia, M; et al. A Cancer-Associated Mutation in Atypical Protein Kinase C iota Occurs in a Substrate-Specific Recruitment Motif. SCIENCE SIGNALING 6:-(2013).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All LLGL2 Products

Required fields are marked with *

My Review for All LLGL2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends