LMAN1
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Official Full Name
lectin, mannose-binding, 1
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Overview
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished. -
Synonyms
LMAN1; lectin, mannose-binding, 1; coagulation factor V factor VIII combined deficiency , F5F8D; protein ERGIC-53; endoplasmic reticulum golgi intermediate compartment protein 53; ERGIC 53; ERGIC53; FMFD1; gp58; MCFD1; MR60; intracellular mannose specific;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LMAN1 Related Articles
LMAN1 involved in several pathways and played different roles in them. We selected most pathways LMAN1 participated on our site, such as Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMAN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | CCDC102A;DNAJC3A;UBQLN4;DNAJA2;DERL1;UBE2E1;LMAN1;RRBP1;MBTPS2 |
LMAN1 has several biochemical functions, for example, mannose binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMAN1 itself. We selected most functions LMAN1 had, and list some proteins which have the same functions with LMAN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannose binding | CD209B;IGF2R;BSG;DPM1;CD207;CD209C;MBL1;MANBA;CD209 |
| metal ion binding | ZNF598;CA5;ZDHHC15A;USP4;LEPREL1;ZNF335;GALNTL2;ZFYVE9;NMRK2 |
| protein binding | COA5;ASB7;PRICKLE1A;PCSK9;DPH2;E2F1;SNRPE;DGCR8;SSX5 |
| unfolded protein binding | HSPE1;CALR3;GRXCR2;TMEM67;MKKS;PFDN2;NPM1;SSUH2RS1;LMAN1 |
LMAN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMAN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMAN1.
SURF4; env; env; ERP44; MCFD2; VHL; q81wb2_bacan; P; PTPN2; TMED5; SNX9
- Q&As
- Reviews
Q&As (6)
Ask a questionThe role of LMAN1 in disease can be assessed through in-depth analysis of the patient's genomic data, combined with the results of studies in cell and animal models. This can help doctors better understand the patient's condition and develop more effective treatment plans.
The function of LMAN1 can be studied through cell models and animal models. For example, the expression of LMAN1 can be manipulated by gene knockout or overexpression techniques and then observed for its effects on cell biology and animal behavior.
Therapeutic strategies for targeting LMAN1 include inhibiting its expression, modulating its activity, or using gene therapy. For example, some small molecule inhibitors can inhibit the activity of LMAN1 to treat some LMAN1-related diseases.
The effect of LMAN1 on disease can be predicted by comparing the expression level, sequence, and structure in different disease tissues and normal tissues. This could help scientists better understand the role of LMAN1 in disease.
In clinical practice, treatment strategies related to LMAN1 need to consider the patient's specific condition, genotype, and treatment goals. Doctors can develop a personalized treatment plan based on the patient's actual situation to improve the treatment effect and maximize the patient's quality of life. At the same time, long-term follow-up and studies are needed to assess the effectiveness and safety of treatment strategies.
Certain biomolecules can be used as molecular markers of LMAN1, such as the mRNA or protein of LMAN1 detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Customer Reviews (3)
Write a reviewLMAN1 has a wide selection of active agents and is soluble in a wide range of active agents.
The activity is maintained for a long time, and the experimental effect is good.
It is easy to use, simple and efficient, and improves the efficiency of scientific research.
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