loxl1
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  • Official Full Name
  • lysyl oxidase-like 1
  • Background
  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
  • Synonyms
  • LOXL1; lysyl oxidase-like 1; LOL; LOXL; lysyl oxidase homolog 1; lysyl oxidase-like protein 1;
Cat.#:LOXL1-1446MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse LOXL1 Protein (95-607 aa), His-tagged
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Cat.#:LOXL1-629MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse LOXL1 Protein (95-607 aa), His-tagged
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Cat.#:LOXL1-268HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LOXL1 Protein, His-tagged
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Cat.#:LOXL1-4732HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LOXL1 Protein, GST-tagged
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Cat.#:Loxl1-270MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Loxl1 Protein, His-tagged
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Cat.#:Loxl1-271RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Loxl1 Protein, His-tagged
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Cat.#:LOXL1-149HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LOXL1, GST-tagged
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Cat.#:LOXL1-9185MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LOXL1 Protein
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Cat.#:LOXL1-3850ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LOXL1
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Cat.#:LOXL1-1028HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human LOXL1 cell lysate
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Involved Pathway

LOXL1 involved in several pathways and played different roles in them. We selected most pathways LOXL1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
COL6A2; TLL2; BMP1B; COL4A5; CTSS; COL1A1; COL8A1A; COL4A6; COL3A1; COL6A1
Collagen formation
COL1A1; TLL2; CTSS; COL16A1; COL28A1D; COL10A1; COL4A6; MMP13; P3H2; PCOLCE2
Crosslinking of collagen fibrils
LOXL4; PCOLCE; BMP1; TLL1; BMP1B; ABHD1; BMP1A; LOXL3; LOXL1; LOXL2
Elastic fibre formation
FBN2; MFAP4; LTBP2; MFAP3; FURINA; MFAP2; ITGB3A; EFEMP1; FURINB; LOXL1
Extracellular matrix organization
COL15A1B; MATN3; TPSAB1; ABHD1; FURINA; DAG1; MMP15; COL9A1; SERPINH1A; COL17A1

Protein Function

LOXL1 has several biochemical functions, for example, copper ion binding, oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL1 itself. We selected most functions LOXL1 had, and list some proteins which have the same functions with LOXL1. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein PARK7; COX17; HIST2H3A; HEPHL1; MOXD1L; MT3; MOXD2; TYRP1B; LOXL2; CCC2
Function oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
Related Protein LOXL3A; LOXL2B; LOXL5A; LOXL5B; LOXL2A; LOXL1; LOXL3B

Interacting Protein

LOXL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL1.
FBLN5; GATAD2B; TFAP2A; ATXN1; TFAP2C

LOXL1 Related Articles

Creasey, R; Sharma, S; et al. Atomic force microscopy-based antibody recognition imaging of proteins in the pathological deposits in Pseudoexfoliation Syndrome. ULTRAMICROSCOPY 111:1055-1061(2011).
Kumarasamy, A; Schmitt, I; et al. Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human Lungs. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 180:1239-1252(2009).
Fujimoto, E; Tajima, S; et al. Reciprocal regulation of LOX and LOXL2 expression during cell adhesion and terminal differentiation in epidermal keratinocytes. JOURNAL OF DERMATOLOGICAL SCIENCE 55:91-98(2009).
Pascual, G; Mendieta, C; et al. Down-regulation of lysyl oxydase-like in aging and venous insufficiency. HISTOLOGY AND HISTOPATHOLOGY 23:179-186(2008).