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LPHN1

  • Official Full Name

    latrophilin 1

  • Overview

    This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
  • Synonyms

    LPHN1; latrophilin 1; latrophilin-1; CIRL1; KIAA0821; LEC2; Calcium independent alpha latrotoxin receptor 1; CL1; Latrophilin1; Lectomedin 2; LPHN 1; CIRL-1; lectomedin-2; calcium-independent alpha-latrotoxin receptor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LPHN1-625H Recombinant Human LPHN1, GST-tagged E.coli GST 1-201aa
Human LPHN1-1029HCL Recombinant Human LPHN1 cell lysate N/A
Human LPHN1-4719H Recombinant Human LPHN1 Protein, GST-tagged Wheat Germ GST
Human LPHN1-2402H Recombinant Human LPHN1 Protein, His-tagged E.coli N-His Val248-Val390
Human LPHN1-5988HF Recombinant Full Length Human LPHN1 Protein In Vitro Cell Free System 343 amino acids
Human LPHN1-4720H Recombinant Human LPHN1 Protein Wheat Germ N/A
Human LPHN1-5990HF Recombinant Full Length Human LPHN1 Protein, GST-tagged In Vitro Cell Free System GST 201 amino acids
Mouse LPHN1-9200M Recombinant Mouse LPHN1 Protein Mammalian Cell His
Mouse LPHN1-5140M Recombinant Mouse LPHN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LPHN1-5140M-B Recombinant Mouse LPHN1 Protein Pre-coupled Magnetic Beads HEK293
Rat LPHN1-3440R Recombinant Rat LPHN1 Protein Mammalian Cell His
Rat LPHN1-3096R Recombinant Rat LPHN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LPHN1-3096R-B Recombinant Rat LPHN1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LPHN1 Related Articles

LPHN1 involved in several pathways and played different roles in them. We selected most pathways LPHN1 participated on our site, such as GPCRs, Class B Secretin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with LPHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
GPCRs, Class B Secretin-likeADCYAP1R1;CRHR1;EMR1;CRHR2;ELTD1;LPHN1;CD97;EMR2;CALCRL

LPHN1 has several biochemical functions, for example, G-protein coupled receptor activity, carbohydrate binding, cell adhesion molecule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LPHN1 itself. We selected most functions LPHN1 had, and list some proteins which have the same functions with LPHN1. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityADRB2B;TMTOPS2B;MRGPRB2;GNRHR3;GPR34L;TAS2R117;TAS2R143;MRGPRA5;BAI1
carbohydrate bindingCD209A;GALNT9;ILLR3;REG1A;MAN2C1;KLRD1;NOMO2;GALNT11;SIGLEC5
cell adhesion molecule bindingCADM2A;PVRL2L;LILRB2;NRXN1;PKP3;CD1D;CDH1;CADM1;NRXN2
latrotoxin receptor activity
protein bindingRNF111;MPDU1;MVK;PAGE1;ATP1B2;HTT;ZBTB24;FCGR2A;CDK16

LPHN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LPHN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LPHN1.

CACNA1A; APC

Davydov, II; Fidalgo, S; et al. Prediction of Epitopes in Closely Related Proteins Using a New Algorithm. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 148:869-873(2009).
Harder, A; Schmitt-Wrede, HP; et al. Cyclooctadepsipeptides - an anthelmintically active class of compounds exhibiting a novel mode of action. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 22:318-331(2003).
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