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LRSAM1

  • Official Full Name

    leucine rich repeat and sterile alpha motif containing 1

  • Overview

    This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways;and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis.;Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding;different isoforms have been identified for this gene.
  • Synonyms

    LRSAM1; leucine rich repeat and sterile alpha motif containing 1; E3 ubiquitin-protein ligase LRSAM1; FLJ31641; E3 ubiquitin protein ligase LRSAM1; EC 6.3.2.-; hTAL; Leucine rich repeat and sterile alpha motif containing protein 1; OTTHUMP00000022174; OTTHUMP00000022175; RIFLE; TAL; Tsg101 associated ligase; Tsg101-associated ligase; leucine-rich repeat and sterile alpha motif-containing protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LRSAM1-29433TH Recombinant Human LRSAM1, His-tagged E.coli His
Human LRSAM1-2342H Recombinant Human LRSAM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LRSAM1-1036HCL Recombinant Human LRSAM1 cell lysate N/A
Human LRSAM1-6111HF Recombinant Full Length Human LRSAM1 Protein, GST-tagged In Vitro Cell Free System GST 723 amino acids
Human LRSAM1-2794H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LRSAM1-4624H Recombinant Human LRSAM1 Protein, GST-tagged Wheat Germ GST
Human LRSAM1-1702H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LRSAM1-2558H Recombinant Human LRSAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Lrsam1-3847M Recombinant Mouse Lrsam1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish LRSAM1-5811Z Recombinant Zebrafish LRSAM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LRSAM1 Related Articles

LRSAM1 involved in several pathways and played different roles in them. We selected most pathways LRSAM1 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LRSAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemKLRB1F;KIF2B;ICAM4;KLHL21;RBCK1;ACTR1B;ASB14;DTX3L;ASB3
Antigen processing: Ubiquitination &ampASB13;RNF220;KLHL20;LRR1;TRIM69;ATG7;TRIM63;ASB14;TRIM11
Proteasome degradationPJA1;UBE2F;ASB17;UBE2V2;ASB10;DTX3L;UFL1;LRSAM1;VPRBP
Class I MHC mediated antigen processing &ampCTSL1;NPEPPS;GAN;RNF111;ASB2;CTSS;SH3RF1;ASB11;RNF6
presentationDTX3L;LTN1;ARIH2;SEC24A;ASB4;FBXO17;RNF41;UBE2J2;ERAP2
Immune SystemSIGLEC8;RNF6;SIGLEC14;DEFB106A;DTX3L;EIF4E3;MASP2;DYNC1LI2;DEFA1

LRSAM1 has several biochemical functions, for example, hormone activity, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LRSAM1 itself. We selected most functions LRSAM1 had, and list some proteins which have the same functions with LRSAM1. You can find most of the proteins on our site.

Function Related Protein
hormone activityTTR;LEPB;CSH2;IGF3;IAPP;POMCA;CCL25;ADM;INS2
ligase activityRNF20;MGRN1A;TTLL13;DTX1;RNF130;CBLB;FPGS;CBLL1;UFL1
protein bindingMAP3K3;SAC3D1;ZBTB33;AXIN1;MRPL11;CD28;SYNPO2L;FGA;FAM46B
ubiquitin protein ligase activitySMURF2;RNF19B;CDC34A;UBE2U;SIAH2L;RFFL;RNF139;CDC42;STUB1
ubiquitin-protein transferase activityUBR5;NHLRC1;RNF115;UBE2D2A;WDSUB1;LNX2B;TRIM36;MARCH5L;UBE2E3
zinc ion bindingSP140;USP51;ZNRF2B;TRIM35-34;C6AST3;TRIM45;FUS;ING1;L3MBTL4

LRSAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LRSAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LRSAM1.

TSG101; UBE2N; TERF1; UBA1; UBE2V1; HSP90AB1; HIP2; TNFRSF10C; MDM4; ATXN7; MYL2; RXRG; UBE2D1

Yang, JCS; Wu, SC; et al. TLR4/NF-kappa B-Responsive MicroRNAs and Their Potential Target Genes: A Mouse Model of Skeletal Muscle Ischemia-Reperfusion Injury. BIOMED RESEARCH INTERNATIONAL :-(2015).
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