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LTK

Official Full Name

leukocyte receptor tyrosine kinase
Overview

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

LTK; leukocyte receptor tyrosine kinase; leukocyte tyrosine kinase; leukocyte tyrosine kinase receptor; TYK1; ALK; Anaplastic lymphoma kinase; LTK_HUMAN; Protein tyrosine kinase 1; TYK 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Zebrafish

Source

HEK293
Insect Cell
Mammalian Cell
Mammalian cells
Sf21
Wheat Germ

Tag

DDK
DDK|His
GST
His
His (Fc)
Avi
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LTK-189H	Active Recombinant Human LTK protein, His-tagged	Mammalian cells	His		Inquiry
Human	LTK-128H	Active Recombinant Human LTK(450-end) Protein, N-GST-tagged	Sf21	GST	450-end	Inquiry
Human	LTK-732H	Recombinant Human LTK Protein, DDK/His-tagged	HEK293	DDK/His		Inquiry
Human	LTK-4586H	Active Recombinant Human LTK Protein, GST-tagged	Insect Cell	GST		Inquiry
Human	LTK-4585H	Recombinant Human LTK Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	LTK-1217H	Recombinant Human LTK Protein, DDK-tagged	Insect Cell	DDK		Inquiry
Human	LTK-0999H	Recombinant Human LTK Protein (K450-S864), GST tagged	Insect Cell	GST	K450-S864	Inquiry
Human	LTK-3403H	Recombinant Human LTK Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	LTK-3403H-B	Recombinant Human LTK Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	LTK-0998H	Recombinant Human LTK Protein (K450-S864), Tag Free	Insect Cell	No tag	K450-S864	Inquiry
Zebrafish	LTK-1613Z	Recombinant Zebrafish LTK	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
LTK Related Articles

LTK involved in several pathways and played different roles in them. We selected most pathways LTK participated on our site, such as neural crest development, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
neural crest development	MSXB;DLX3B;DLX4A;SOX9B;PHOX2BB;LTK;DLX2A;PLP1B;EGR2B

LTK has several biochemical functions, for example, ATP binding, kinase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTK itself. We selected most functions LTK had, and list some proteins which have the same functions with LTK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	PRKCQ;AK3;HARS;UBE2Z;MAPK12B;PAK3;RTEL1;DDX3;CLK2B
kinase activity	PKMYT1;CDK14;LRRK2;PLK2B;EPHA2A;PFKMB;PKZ;PPM1E;PTK2BB
nucleotide binding	PFKMA;LRGUK;PLK2B;RBMS3;PRKCDA;CHD8;RBM33;STK25A;RNPS1
protein kinase activity	TBCK;TRIM24;INSRB;PKDCCA;NRBP2;DYRK1B;PTK6B;PRPF4B;JAK2B
protein tyrosine kinase activity	BAZ1B;PTK2AA;MAP2K6;BTK;FYN;FGFR1B;EPHB2B;IGF1RA;JAK1
transferase activity	TSSK5;EGFRA;NUCKS1A;KAT7B;OXCT2A;GNPTAB;EPHB3A;JAK2B;CDK5R1A
transmembrane receptor protein tyrosine kinase activity	EGFRA;ROS1;FLT3;NTRK2B;AXL;INSRB;TRIM27;KIT;MERTK

LTK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTK here. Most of them are supplied by our site. Hope this information will be useful for your research of LTK.

Roll, JD; Reuther, GW; et al. ALK-Activating Homologous Mutations in LTK Induce Cellular Transformation. PLOS ONE 7:-(2012).

Morris, SJ; Van-Ham, II; et al. Differential desensitization of dopamine D-2 receptor isoforms by protein kinase C: The importance of receptor phosphorylation and pseudosubstrate sites. EUROPEAN JOURNAL OF PHARMACOLOGY 577:44-53(2007).