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LUM

  • Official Full Name

    lumican

  • Overview

    This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
  • Synonyms

    LUM; lumican; LDC; lumican proteoglycan; SLRR2D; Keratan sulfate proteoglycan lumican; KSPG Lumican; LUM_HUMAN; Lumican precursor; OTTHUMP00000242889;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LUM-29148TH Recombinant Human LUM Wheat Germ N/A 338 amino acids
Human LUM-154H Recombinant Human LUM protein, His-tagged HEK293 His Gln19-Asn338
Human LUM-32H Recombinant Human LUM protein, His-tagged Insect Cell His
Human LUM-3223H Recombinant Human LUM, His tagged HEK293 His Met 1-Asn 338
Human LUM-2491H Recombinant human LUM, His-tagged E.coli His
Human LUM-2210HCL Recombinant Human LUM cell lysate Human Cell N/A
Human LUM-822H Recombinant Human LUM Protein, His-tagged HEK293 His
Human LUM-290HF Recombinant Full Length Human LUM Protein In Vitro Cell Free System 338 amino acids
Human LUM-1220H Recombinant Human LUM Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LUM-4470H Recombinant Human LUM Protein (Gln19-Asn338), C-His tagged Mammalian cells C-His Gln19-Asn338
Human LUM-4471H Recombinant Human LUM Protein (Gln19-Asn338), N-His tagged E.coli N-His Gln19-Asn338
Mouse Lum-7046M Recombinant Mouse Lum protein, His-tagged E.coli His Gln19~Asn338
Mouse LUM-9360M Recombinant Mouse LUM Protein Mammalian Cell His
Mouse LUM-5244M Recombinant Mouse LUM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse LUM-5244M-B Recombinant Mouse LUM Protein Pre-coupled Magnetic Beads HEK293
Mouse Lum-3866M Recombinant Mouse Lum Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Lum-4059M Recombinant Mouse Lum Protein (Gln19-Asn338), C-His tagged Mammalian cells C-His Gln19-Asn338
Mouse Lum-3188M Recombinant Mouse Lum protein, His&Myc-tagged E.coli His&Myc 19-338aa
Rat LUM-3504R Recombinant Rat LUM Protein Mammalian Cell His
Rat LUM-3160R Recombinant Rat LUM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Lum-5035R Recombinant Rat Lum protein, His-tagged HEK293 His 19-338aa
Rat LUM-3160R-B Recombinant Rat LUM Protein Pre-coupled Magnetic Beads HEK293
Rat LUM-1936R Recombinant Rat LUM Protein (19-338 aa), His-tagged E.coli His 19-338 aa
Rhesus Macaque LUM-2593R Recombinant Rhesus monkey LUM Protein, His-tagged Mammalian Cell His
Rhesus Macaque LUM-2413R Recombinant Rhesus Macaque LUM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LUM-2413R-B Recombinant Rhesus Macaque LUM Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LUM-293Z Recombinant Zebrafish LUM Mammalian Cell His
Chicken LUM-4709C Recombinant Chicken LUM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LUM Related Articles
  • LUM Related Research Area

LUM involved in several pathways and played different roles in them. We selected most pathways LUM participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LUM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Proteoglycans in cancerFzd4;PTPN11;GAB1;CBL;NRAS;MMP2;FZD3;MAPK1;PIK3CD

LUM has several biochemical functions, for example, collagen binding, extracellular matrix structural constituent, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LUM itself. We selected most functions LUM had, and list some proteins which have the same functions with LUM. You can find most of the proteins on our site.

Function Related Protein
collagen bindingMMP13;VWF;CTSL1;HSD17B12;LUM;Pdgfa&Pdgfb;CHADL;MMP9;MRC2
extracellular matrix structural constituentCHI3L1;COL1A1;FBN2B;COL1A1A;COL4A3;COL4A6;COL11A1A;COL27A1B;COL11A1B
protein bindingMTTP;TSGA10;IL33;GRB2;CYSLTR2;UBE2D1;RBM39;LILRB3;TEN1

LUM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LUM here. Most of them are supplied by our site. Hope this information will be useful for your research of LUM.

MMP14; GNAQ; TRA2B; d-mannose

Dupuis, LE; Kern, CB; et al. Small Leucine- Rich Proteoglycans Exhibit Unique Spatiotemporal Expression Profiles During Cardiac Valve Development. DEVELOPMENTAL DYNAMICS 243:601-611(2014).
Yeh, JT; Yeh, LK; et al. Impaired skin wound healing in lumican-null mice. BRITISH JOURNAL OF DERMATOLOGY 163:1174-1180(2010).
  • Q&As
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