Lbp
-
Official Full Name
lipopolysaccharide binding protein
-
Overview
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene. -
Synonyms
LBP; lipopolysaccharide binding protein; lipopolysaccharide-binding protein; BPI fold containing family D; member 2; BPIFD2; Ly88; BPI fold containing family D, member 2; LBP_HUMAN; LBP1; LPS binding protein; MGC22233; OTTHUMP00000030965; RP23-407H16.4; LPS-binding protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chromatography Reagents
- Cattle
- Human
- Mouse
- Pig
- Rabbit
- Rat
- CHO
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- NS0
- Wheat Germ
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Lbp Related Articles
- Lbp Related Research Area
Lbp involved in several pathways and played different roles in them. We selected most pathways Lbp participated on our site, such as NF-kappa B signaling pathway, Toll-like receptor signaling pathway, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lbp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TRAF3;TLR4;ERC1;VCAM1;CCL21B;NFKB2;PRKCB;BCL2A1;LAT |
| Toll-like receptor signaling pathway | IFNA16;MAP2K4;CCL4;MAPK10;MAPK12;IFNA4;CASP8;CD40;TOLLIP |
| Salmonella infection | RELA;TLR4;CXCL8B.3;NOS2A;MAPK8B;ARPC5A;MAPK8;DYNC1I2A;KLC1A |
| Tuberculosis | CD209A;IRAK1;FCER1G;IFNA8;MAPK10;IL1A;STAT1;MRC2;SPHK1 |
Lbp has several biochemical functions, for example, lipopolysaccharide binding, lipoteichoic acid binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Lbp itself. We selected most functions Lbp had, and list some proteins which have the same functions with Lbp. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipopolysaccharide binding | BPI;LBP;DROSHA;SCARB1;SPON2;TLR2;HSPD1;HMGB1;PSMB4 |
| lipoteichoic acid binding | TLR2;CD14;CD6;TREM2;LBP |
| protein binding | KRTAP9-4;IMMT;COL13A1;CHTOP;SLC4A4;ABHD1;NAPA;ZFP746;TRPV4 |
| receptor binding | APP;IL28A;PVRL4;ACOX1;CSNK2B;DAO1;NOS2;LAMA4;PEX14 |
Lbp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lbp here. Most of them are supplied by our site. Hope this information will be useful for your research of Lbp.
PRDX4; SETD1A; CBFA2T2; FTH1; C4BPA; HSPB1; PSMA3; BAG6; SMAD3; BST1; TRA2A; PYCRL; TSC22D4; d-mannose
- Q&As
- Reviews
Q&As (7)
Ask a questionIf LPS's chemical spatial configuration prevents close contact with TLR4, it exhibits an antagonistic effect, inhibiting the cellular response.
LPS on the LBP-LPS complex, upon close physical contact with TLR4 on cells, induces TLR4 receptor dimerization or multimerization. This activates various transcription factors, leading to the expression of inflammatory mediators and cytokines.
For cells without membrane CD14 receptors (e.g., endothelial and epithelial cells), a soluble CD14 (sCD14)-LBP-LPS ternary complex forms, activating TLR4 and inducing various biological effects.
LBP stands for Lipopolysaccharide-Binding Protein.
LBP has a high affinity for the lipid A portion in the structure of Lipopolysaccharide (LPS) and forms the LPS-LBP complex.
Liver cells, similar to macrophages, express mCD14 and TLR4. In the absence of CD14 receptors, LPS can still bind to TLR4, but with relatively weaker intensity.
The LBP-LPS complex can transfer LPS to membrane CD14 (mCD14) receptors on cells like monocytes, macrophages, and neutrophils.
Customer Reviews (3)
Write a reviewWe appreciated the product's efforts to minimize its environmental footprint through sustainable manufacturing practices.
Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.
The product's versatility allowed us to apply it to a wide range of experimental techniques and research areas.
Ask a Question for All Lbp Products
Required fields are marked with *
My Review for All Lbp Products
Required fields are marked with *
