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LDLRAP1

Official Full Name

low density lipoprotein receptor adaptor protein 1
Overview

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia. [provided by RefSeq, Jul 2008]
Synonyms

LDLRAP1; low density lipoprotein receptor adaptor protein 1; ARH; ARH1; ARH2; FHCB1; FHCB2; low density lipoprotein receptor adapter protein 1; LDL receptor adaptor protein; autosomal recessive hypercholesterolemia protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
His|T7
MYC
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	LDLRAP1-1396H	Recombinant Human Low Density Lipoprotein Receptor Adaptor Protein 1, His-tagged	E.coli	His		Inquiry
Human	LDLRAP1-4784HCL	Recombinant Human LDLRAP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	LDLRAP1-301431H	Recombinant Human LDLRAP1 protein, GST-tagged	E.coli	GST	Met1-Phe308	Inquiry
Mouse	LDLRAP1-9029M	Recombinant Mouse LDLRAP1 Protein	Mammalian Cell	His		Inquiry
Mouse	Ldlrap1-7874M	Recombinant Mouse Ldlrap1 protein, His & T7-tagged	E.coli	His/T7	Met1~Phe308	Inquiry
Mouse	Ldlrap1-005M	Recombinant Mouse Ldlrap1 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Mouse	LDLRAP1-5026M	Recombinant Mouse LDLRAP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	LDLRAP1-5026M-B	Recombinant Mouse LDLRAP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
LDLRAP1 Related Articles

LDLRAP1 involved in several pathways and played different roles in them. We selected most pathways LDLRAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDLRAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	CAPZA3;HSPA8;HGS;RAB11FIP2;CHMP6;SPG20;CAPZA1B;GRK6;DNM2B

LDLRAP1 has several biochemical functions, for example, AP-2 adaptor complex binding, beta-amyloid binding, clathrin adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LDLRAP1 itself. We selected most functions LDLRAP1 had, and list some proteins which have the same functions with LDLRAP1. You can find most of the proteins on our site.

Function	Related Protein
AP-2 adaptor complex binding	LDLRAP1;AAK1;ARRB1;OTOF;TBC1D5;FCHO1
beta-amyloid binding	APOEA;BACE2;MAPK8IP2;ACHE;ITM2C;FBXO2;BCHE;APBB3;OLFM1
clathrin adaptor activity	PICALM;ARRB1;DAB2;LDLRAP1
clathrin binding	RPH3A;SYT5B;SYTL4;SYT5A;NCALD;HIP1R;SYT4;SYT1;SMAP1
low-density lipoprotein particle receptor binding	APOEA;APOB;APOE;APOEB;HSP90B1;MESDC2;SLC9A3R2;MMP13;LRPAP1
phosphatidylinositol-4,5-bisphosphate binding	CHMP3;PFN1;LDLRAP1;EXOC1;PHLDA3;SNX20;SNX21;COMMD1;FCHO2
phosphotyrosine binding	LDLRAP1;SAMSN1;CBLC;MAPK1;FGR;STAP1;CBL;SHC1;CBLB
protein binding	FZD8;SPRR2E;UBE2D2A;NCOA1;GOLSYN;TRAPPC6A;TBC1D22B;MINK1;CLCF1
receptor signaling complex scaffold activity	NCK1;CD3E;AXIN1;RGS14;LDLRAP1;ROPN1B;GRIP1;MMS19;SPAG9
signaling adaptor activity	SH2B3;AFAP1L2;MPP7;HOMER1;LDLRAP1;GNB2L1;SH2B1;SH2B2

LDLRAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDLRAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LDLRAP1.

AP2B1; OBFC1; LDLR; Klc1; CLTC; Lrp2; SNW1

Yang, XV; Banerjee, Y; et al. Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106:274-279(2009).

Gaultier, A; Arandjelovic, S; et al. Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappa B pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. BLOOD 111:5316-5325(2008).