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LIG1

  • Official Full Name

    ligase I, DNA, ATP-dependent

  • Overview

    LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process.Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
  • Synonyms

    LIG1; ligase I, DNA, ATP-dependent; DNA ligase 1; polydeoxyribonucleotide synthase [ATP] 1; MGC117397; MGC130025;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIG1-1519H Recombinant Human LIG1 protein E.coli N/A
Human LIG1-26930TH Recombinant Human LIG1, His-tagged E.coli His
Human LIG1-985HCL Recombinant Human LIG1 cell lysate N/A
Human LIG1-3175H Recombinant Human LIG1 protein, GST-tagged E.coli GST 1-919aa
Human LIG1-1293H-B Recombinant Human LIG1 Protein Pre-coupled Magnetic Beads HEK293
Human LIG1-1293H Recombinant Human LIG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LIG1-3849H Recombinant Human LIG1 protein, His-tagged E.coli His 670-919 aa
Human LIG1-4446H Recombinant Human LIG1 Protein (Gly484-Ile663), N-His tagged E.coli N-His Gly484-Ile663
Human LIG1-196HFL Active Recombinant Full Length Human LIG1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Lig1-1318M Recombinant Mouse Lig1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Lig1-6751R Recombinant Rat Lig1 protein, His & T7-tagged E.coli His/T7 Lys568~Phe875 (Accession # Q9JHY8)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIG1 Related Articles

LIG1 involved in several pathways and played different roles in them. We selected most pathways LIG1 participated on our site, such as DNA replication, Base excision repair, Nucleotide excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA replicationPOLD4;MCM10;POLD1;POLD2;DNA2;RNASEH2A;CDT1;DBF4;SSBP1
Base excision repairTDG.1;NEIL2;POLE2;OGG1;HMGB1;nth;APEX1;PARP2;APEX2
Nucleotide excision repairUSP45;PCNA;RFC3;KIAA1530;COPS6;MNAT1;NFRKB;POLE2;CHD1L
Mismatch repairSSBP1;RFC5;POLD1;RPA4;MSH3;POLD2;RPA1;POLD4;MLH1

LIG1 has several biochemical functions, for example, ATP binding, DNA binding, DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIG1 itself. We selected most functions LIG1 had, and list some proteins which have the same functions with LIG1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingMAPK11;EIF4A3;ATP2B1B;MAP2K2B;MYH7B;PIP5K1B;UBE2K;DYNC2H1;NSFB
DNA bindingHOXA11B;FANCI;HOXC6A;CDKN2A;MIER1;APLP2;HLFA;SOX21A;ZFP30
DNA ligase (ATP) activityLIG4;LIG3;LIG1
DNA ligase activityLIG4;LIG3;LIG1
metal ion bindingCALUA;FAH;MAP3K13;ZBTB4;ZNF710A;HDAC9;SETDB1A;FHL1B;PRKCBA

LIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIG1.

TUBB4A; HSPB1; RGS2; INPP1; Lyplal1; AURKA; Tgs1

Linke, M; May, A; et al. The Impact of Ovarian Stimulation on the Expression of Candidate Reprogramming Genes in Mouse Preimplantation Embryos. CYTOGENETIC AND GENOME RESEARCH 139:71-79(2013).
Cordoba-Canero, D; Roldan-Arjona, T; et al. Arabidopsis ARP endonuclease functions in a branched base excision DNA repair pathway completed by LIG1. PLANT JOURNAL 68:693-702(2011).
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