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LIPA

  • Official Full Name

    lipase A, lysosomal acid, cholesterol esterase

  • Overview

    This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
  • Synonyms

    LIPA; lipase A, lysosomal acid, cholesterol esterase; LAL; CESD; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Bartonella Henselae
  • Burkholderia cepacia
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rochalimaea henselae
  • Bacillus subtilis
  • E. coli or Yeast
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIPA-11H Recombinant Human LIPA, MYC/DDK-tagged HEK293 Myc/DDK
Human LIPA-4727HCL Recombinant Human LIPA 293 Cell Lysate HEK293 N/A
Human LIPA-627H Recombinant Human LIPA Protein (22-399 aa), GST-tagged E.coli GST 22-399 aa
Human LIPA-2158H Recombinant Human LIPA Protein (22-399 aa), His-tagged Yeast His 22-399 aa
Human LIPA-7697HFL Recombinant Full Length Human LIPA, Flag-tagged Mamanlian cells Flag
Human LIPA-6304H Recombinant Human LIPA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Lipa-7937M Recombinant Mouse Lipa protein, His & T7-tagged E.coli His/T7 Asn32~Val201 (Accession # Q9Z0M5)
Mouse Lipa-1321M Recombinant Mouse Lipa Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Lipa-7938R Recombinant Rat Lipa protein, His & T7-tagged E.coli His/T7 Asn32~Ile358 (Accession # Q64194)
Rat Lipa-1171R Recombinant Rat Lipa protein, His-tagged E.coli His 26-397aa
Rat Lipa-1284R Recombinant Rat Lipa protein, His-tagged Insect Cell His 26-397aa
Bacillus subtilis LIPA-2533B Recombinant Bacillus subtilis LIPA protein, His-tagged E. coli or Yeast His
Bartonella Henselae LIPA-2402B Recombinant Bartonella Henselae LIPA Protein (1-320 aa), His-tagged Yeast His 1-320 aa
Burkholderia cepacia lipA-1243B Recombinant Burkholderia cepacia lipA Protein (Thr26-Val363), C-His tagged Bacillus subtilis C-His Thr26-Val363
Rhesus Macaque LIPA-2523R Recombinant Rhesus monkey LIPA Protein, His-tagged Mammalian Cell His
Rhesus Macaque LIPA-2343R Recombinant Rhesus Macaque LIPA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LIPA-2343R-B Recombinant Rhesus Macaque LIPA Protein Pre-coupled Magnetic Beads HEK293
Rochalimaea henselae lipA-4573R Recombinant Rochalimaea henselae lipA protein, His-tagged E.coli His 1-320aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIPA Related Articles

LIPA involved in several pathways and played different roles in them. We selected most pathways LIPA participated on our site, such as Steroid biosynthesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Steroid biosynthesisSC4MOL;SQLE;LIPA;EBP;HSD17B7;SC5D;SOAT2;FAXDC2;NSDHL
LysosomeCTSG;AP3S1;GNS;LAMP2;NAGA;CTSLA;ATP6V0A4;NAGPA;CTSSA

LIPA has several biochemical functions, for example, lipase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIPA itself. We selected most functions LIPA had, and list some proteins which have the same functions with LIPA. You can find most of the proteins on our site.

Function Related Protein
lipase activityNOTUM1A;LIPM;CES1C;DAGLB;LIPA;ABHD2B;Aadacl3;CELL;PNPLA7
sterol esterase activityCES3;CES1D;CEL.1;CES1;Cel;LIPA;CES5A

LIPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIPA here. Most of them are supplied by our site. Hope this information will be useful for your research of LIPA.

Frohnecke, N; Klein, S; et al. Protein-protein interaction studies provide evidence for electron transfer from ferredoxin to lipoic acid synthase in Toxoplasma gondii. FEBS LETTERS 589:31-36(2015).
Zhao, FH; Zhu, FC; et al. Baseline prevalence and type distribution of human papillomavirus in healthy Chinese women aged 18-25 years enrolled in a clinical trial. INTERNATIONAL JOURNAL OF CANCER 135:2604-2611(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does LIPA protein deficiency affect lipid metabolism? 04/30/2021

LIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.

How is LIPA protein deficiency diagnosed? 09/14/2020

Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.

Are there any specific dietary recommendations for individuals with LIPA protein deficiency? 03/23/2020

Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.

How does LIPA protein deficiency affect the liver? 01/06/2019

LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.

Are there any ongoing research efforts focused on LIPA protein and its clinical applications? 05/19/2016

Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.

Customer Reviews (3)

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Reviews
03/02/2019

    Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

    01/18/2018

      The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

      03/05/2017

        Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

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