LIPA
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Official Full Name
lipase A, lysosomal acid, cholesterol esterase
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Overview
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014] -
Synonyms
LIPA; lipase A, lysosomal acid, cholesterol esterase; LAL; CESD; lysosomal acid lipase/cholesteryl ester hydrolase; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Bartonella Henselae
- Burkholderia cepacia
- Human
- Mouse
- Rat
- Rhesus Macaque
- Rochalimaea henselae
- Bacillus subtilis
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Yeast
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LIPA Related Articles
LIPA involved in several pathways and played different roles in them. We selected most pathways LIPA participated on our site, such as Steroid biosynthesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Steroid biosynthesis | SC4MOL;SQLE;LIPA;EBP;HSD17B7;SC5D;SOAT2;FAXDC2;NSDHL |
Lysosome | CTSG;AP3S1;GNS;LAMP2;NAGA;CTSLA;ATP6V0A4;NAGPA;CTSSA |
LIPA has several biochemical functions, for example, lipase activity, sterol esterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIPA itself. We selected most functions LIPA had, and list some proteins which have the same functions with LIPA. You can find most of the proteins on our site.
Function | Related Protein |
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lipase activity | NOTUM1A;LIPM;CES1C;DAGLB;LIPA;ABHD2B;Aadacl3;CELL;PNPLA7 |
sterol esterase activity | CES3;CES1D;CEL.1;CES1;Cel;LIPA;CES5A |
LIPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIPA here. Most of them are supplied by our site. Hope this information will be useful for your research of LIPA.
- Q&As
- Reviews
Q&As (5)
Ask a questionLIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.
Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.
Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.
LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.
Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.
Customer Reviews (3)
Write a reviewIts reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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