LMNA
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Official Full Name
Lamin A/C
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Overview
Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene.[1][2] Lamin A/C belongs to the lamin family of proteins. -
Synonyms
LMNA; lamin A/C; cardiomyopathy, dilated 1A (autosomal dominant) , CMD1A,lamin A/C like 1 , LGMD1B,limb girdle muscular dystrophy 1B (autosomal dominant) , LMN1, LMNL1, PRO1,progeria 1 (Hutchinson Gilford type); prelamin-A/C; HGPS; 70 kDa Lamin; Cardiomyopathy dilated 1A (autosomal dominant); CDCD1; CDDC; Charcot Marie Tooth Disease Axonal Type 2B1; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; Lamin A/C; Lamin A/C Isoform 1 Precursor; Lamin A/C Isoform 2; Lamin A/C Isoform 3; Lamin-A/C; LDP1; LFP; LGMD1B; Limb girdle muscular dystrophy 1B (autosomal dominant); LMN 1; LMN A; LMN C; LMN1; LMNA; LMNA_HUMAN; LMNC; NY REN 32 antigen; PRO1; Progeria 1 (Hutchinson Gilford Type); Renal carcinoma antigen NY REN 32; Renal carcinoma antigen NY-REN-32; Renal carcinoma antigen NYREN32; lamin-A/C; 70 kDa lamin; lamin A/C-like 1; OTTHUMP00000015843; OTTHUMP00000015845; OTTHUMP00000015846; OTTHUMP00000015847; OTTHUMP00000015848; OTTHUMP00000217835; renal carcinoma antigen NY-REN-32; FPL; IDC; LFP; CDDC; EMD2; FPLD; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- LMNA Related Articles
LMNA involved in several pathways and played different roles in them. We selected most pathways LMNA participated on our site, such as Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | ITGB8;SGCA;ACE;CACNA2D4;IL6;CACNG1;ATP2A2;CACNB2;EMD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCD;ITGA6;ATP2A2;AASS;ITGAV;ITGB3;CTNNA1;CACNG6;ITGB5 |
| Dilated cardiomyopathy | MYL3;ITGB3;Itga10&Itgb1;ITGA3;CACNB2;TNF;CACNG2;ITGA2;CACNA2D1 |
LMNA has several biochemical functions, for example, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LMNA itself. We selected most functions LMNA had, and list some proteins which have the same functions with LMNA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CHERP;WDR11;RAG1;CCDC121;CRY1;DNAJB1;LILRB2;EIF3A;ZNF18 |
| structural molecule activity | KRT27;CLDNJ;KRT96;TUBG2;GNL1;LLGL1;CLDN20;KRT38;TUBA1A |
LMNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMNA here. Most of them are supplied by our site. Hope this information will be useful for your research of LMNA.
H2AFX; SUN2; KRTAP10-7; YWHAZ; DUSP13; MYC
- Q&As
- Reviews
Q&As (7)
Ask a questionLMNA interacts with various structural proteins, playing a key role in the nuclear architecture.
Genetic alterations in LMNA can impair the structural stability of the nucleus, affecting overall cell function.
Targeting LMNA mutations could offer therapeutic strategies for conditions like progeria and cardiac diseases.
LMNA, encoding lamin proteins, is vital for maintaining the structural integrity of the nucleus in cells.
It contributes to nuclear envelope stability, ensuring proper nuclear shape and mechanical support.
LMNA mutations are associated with progeria, leading to premature aging and related phenotypes.
Altered LMNA activity is linked to cardiovascular diseases, influencing heart muscle function and structure.
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