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LMO2

  • Official Full Name

    LIM domain only 2 (rhombotin-like 1)

  • Overview

    LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    LMO2; LIM domain only 2 (rhombotin-like 1); RBTNL1; rhombotin-2; RBTN2; RHOM2; rhombotin like 1; T cell translocation gene 2; TTG2; LMO-2; rhombotin 2; rhombotin-like 1; LIM domain only protein 2; T-cell translocation gene 2; cysteine-rich protein TTG-2; T-cell translocation protein 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LMO2-4710HCL Recombinant Human LMO2 293 Cell Lysate HEK293 N/A
Human LMO2-777H Recombinant Human LMO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LMO2-2611H Recombinant Human LMO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LMO2-6221H Recombinant Human LMO2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LMO2-2399H Recombinant Human LMO2 Protein, His-tagged E.coli N-His Met1-Gly156
Mouse Lmo2-1327M Recombinant Mouse Lmo2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque LMO2-2534R Recombinant Rhesus monkey LMO2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LMO2-2354R-B Recombinant Rhesus Macaque LMO2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque LMO2-2354R Recombinant Rhesus Macaque LMO2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish LMO2-8735Z Recombinant Zebrafish LMO2 Mammalian Cell His
Chicken LMO2-5844C Recombinant Chicken LMO2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LMO2 Related Articles
  • LMO2 Related Research Area

LMO2 involved in several pathways and played different roles in them. We selected most pathways LMO2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerNFKB1;MMP3;MAF;TFE3;FUS;GOLPH3;FCGR1A;CEBPE;RXRA

LMO2 has several biochemical functions, for example, E-box binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMO2 itself. We selected most functions LMO2 had, and list some proteins which have the same functions with LMO2. You can find most of the proteins on our site.

Function Related Protein
E-box bindingMYC;ZEB1;MYOG;NEUROD2;LMO2;NEUROG1;CLOCK;TCF4;NEUROG2
RNA polymerase II activating transcription factor bindingCTNNB1;ATF2;TBX3;HNF4A;DUSP26;ISL1;EOMES;EP300;TBX20
RNA polymerase II regulatory region sequence-specific DNA bindingBARX1;CSDA;EOMES;NHLH1;PHOX2B;ZFP551;OSR2;HES6;AASS
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXO3A;FOXD5;FOXG1C;FOXJ1;FOXC1A;TFDP3;FOXJ1B;FOXO1;JUN
bHLH transcription factor bindingUSF1;LMO2;TWIST1;PSMD9;SOX9;SMAD3;ISL1;HAND1;TCF12
chromatin bindingTWIST2;RBPJL;C10orf119;GLI1;CBX4;CREB3;SP140L;STAG2;RBMX
cofactor bindingTYMS;LMO2;UROS;PGAM2;C3;DAO;WWOX;HIF1AN;HACL1
protein bindingERO1LB;BMP4;NR4A3;SF1;TRIM23;ACAA2;GSTK1;ACBD3;MRPL40
transcriptional activator activity, RNA polymerase II transcription factor bindingNFE2L1;FOXH1;SOX10;MIXL1;PPARA;KLF4;WWP2;PITX1;NKX2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGLIS1;TRP53;MAFB;LEF1;SRF;AIRE;GATA4;MSX1;BARHL1A
zinc ion bindingRNF11A;ERAP2;ZBTB32;CBL;RXRG;ZCCHC10;ABLIM1A;BAZ2A;BIRC8

LMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMO2.

MAPRE3; HNRNPM; MAPRE2; LDB1; PHC2

Zhang, J; Rabbitts, TH; et al. Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1970-1976(2014).
Sewell, H; Tanaka, T; et al. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. SCIENTIFIC REPORTS 4:-(2014).
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