loxl3
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  • Official Full Name
  • lysyl oxidase-like 3
  • Background
  • This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the;biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first;step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus;end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function.;The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor;suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript;variants of this gene have been reported but their full-length nature has not been determined.
  • Synonyms
  • LOXL3; lysyl oxidase-like 3; LOXL; lysyl oxidase homolog 3; lysyl oxidase-like protein 3; EC 1.4.3.13
Cat.#:LOXL3-277HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LOXL3 Protein, His-tagged
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Cat.#:LOXL3-4730HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human LOXL3 Protein, GST-tagged
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Cat.#:Loxl3-278MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Loxl3 Protein, His-tagged
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Cat.#:LOXL3-1979HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Lysyl Oxidase-Like 3, His-tagged
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Cat.#:LOXL3-132HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human LOXL3, GST-tagged
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Cat.#:LOXL3-9187MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse LOXL3 Protein
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Involved Pathway

LOXL3 involved in several pathways and played different roles in them. We selected most pathways LOXL3 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen formation, Crosslinking of collagen fibrils, which may be useful for your reference. Also, other proteins which involved in the same pathway with LOXL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
CTSL1; COL6A2; CD151; COL3A1; CTSB; ABHD1; COL5A1; COL10A1; COL5A3A; COL11A1B
Collagen formation
COL28A1D; TLL2; COL15A1B; COL3A1; PCOLCE; COL4A3; COL28A1; COL6A1; COL2A1; BMP1B
Crosslinking of collagen fibrils
LOXL3; LOXL1; BMP1; BMP1B; LOX; LOXL2; BMP1A; TLL1; ABHD1; TLL2
Elastic fibre formation
LOX; ABHD1; MFAP3; LOXL1; LTBP3; FURINA; MFAP2; EFEMP2; LOXL4; FBN1
Extracellular matrix organization
COL25A1; COL28A1; FURINA; CRTAP; LOXL2; LAMB1B; COL4A5; MFAP2; COL11A1B; DAG1

Protein Function

LOXL3 has several biochemical functions, for example, copper ion binding, protein binding, protein-lysine 6-oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LOXL3 itself. We selected most functions LOXL3 had, and list some proteins which have the same functions with LOXL3. You can find most of the proteins on our site.
Function
Related Protein
Function copper ion binding
Related Protein SNCA; DBH; ATP7B; PRND; COMMD1; ANG; LOX; SOD1; ATOX1; AOC3
Function protein binding
Related Protein GLIS2; GOPC; IL7; FAM59A; DHRS1; CIAO1; RPS6KC1; C8orf74; FMR1; RNF138
Function protein-lysine 6-oxidase activity
Related Protein LOXL2B; LOXL3; LOXL4; ABHD1; LOX; LOXL2; LOXL2A; POLR1B
Function scavenger receptor activity
Related Protein PRG4; ENDOU; GM106; CXCL16; LOXL3B; C8orf84; POLR1B; ENPP2; SCARA5; SRCRB4D

Interacting Protein

LOXL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LOXL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LOXL3.
GATAD2B; APMAP