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LTA

  • Official Full Name

    lymphotoxin alpha (TNF superfamily, member 1)

  • Overview

    The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin''''s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
  • Synonyms

    LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bacillus subtilis
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • S. aureus
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293T
  • Hordeum Vulgare
  • Human
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Wheat Germ
  • Biotin
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|Flag|StrepII
  • His|T7
  • HQ
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LTA-165H Active Recombinant Human Lymphotoxin Alpha (TNF Superfamily, Member 1) HEK293 N/A
Human LTA-554H Active Recombinant Human LTA protein E.coli N/A Leu35-Leu205
Human LTA-051H Active Recombinant Human LTA protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Leu35-Leu205
Human LTA-4367H Active Recombinant Human LTA protein, His-tagged Mammalian cell His 35-205aa
Human LTA-214H Active Recombinant Human LTA Protein (Leu1-Leu171), N-His tagged, Animal-free, Carrier-free E.coli N-His Leu1-Leu171
Human LTA-31074TH Recombinant Human LTA, His-tagged E.coli His
Human LTA-310H Recombinant Human LTA protein E.coli N/A 171
Human LTA-31535TH Recombinant Human LTA E.coli N/A
Human LTA-5067H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1) Human N/A
Human LTA-31534TH Recombinant Human LTA, His-tagged His
Human LTA-311H Recombinant Human Lymphotoxin Alpha, His-tagged E.coli His
Human LTA-221H Recombinant Human LTA, StrepII-tagged Human Cell Strep II 35-205, 171 a.a.
Human LTA-1253H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 1), HQ-tagged Hordeum Vulgare HQ
Human LTA-31536TH Recombinant Human LTA, His-tagged His
Human LTA-568H Recombinant Human LTA protein, His & T7-tagged E.coli His/T7 Pro36~Leu205 (Accession # P01374)
Human LTA-260H Recombinant Human Lymphotoxin Alpha Insect Cell N/A
Human LTA-5068H Recombinant Human Lymphotoxin Alpha (TNF superfamily, member 2), His-tagged Human His
Human LTA-9167HCL Recombinant Human LTA 293 Cell Lysate HEK293 N/A
Human DMABT-H19263 Mouse Anti-LTA Monoclonal Antibody Mouse N/A
Human LTA-1223H Recombinant Human LTA Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human Lta-070H Recombinant Human Lta Protein 233
Human TNFB-89H Human Tumour Necrosis Factor beta (rDNA derived) Reference standard N/A
Human DMABT-H19264 Mouse Anti-LTA Monoclonal Antibody Mouse Biotin
Human LTA-6059HF Recombinant Full Length Human LTA Protein, GST-tagged In Vitro Cell Free System GST 205 amino acids
Human LTA-4597H Recombinant Human LTA Protein, GST-tagged Wheat Germ GST
Human LTA-4599H Recombinant Human LTA Protein, His/Flag/StrepII-tagged Human cells His/Flag/StrepII
Human LTA-2131HFL Recombinant Full Length Human LTA Protein, C-Flag-tagged Mammalian cells Flag
Human LTA-1323H Recombinant Human LTA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LTA-1323H-B Recombinant Human LTA Protein Pre-coupled Magnetic Beads HEK293
Human LTA-4465H Recombinant Human LTA Protein (Leu35-Leu205), His tagged E.coli His Leu35-Leu205
Mouse Lta-66M Active Recombinant Mouse Lta Protein (Leu34-Leu202), N-His tagged, Animal-free, Carrier-free E.coli N-His Leu34-Leu202
Mouse Lta-569M Recombinant Mouse Lta protein, His-tagged E.coli His Pro49~Leu202 (Accession # P09225)
Mouse LTA-9342M Recombinant Mouse LTA Protein Mammalian Cell His
Mouse Lta-3187M Recombinant Mouse Lta protein, His&Myc-tagged E.coli His&Myc 34-202aa
Mouse LTA-5234M-B Recombinant Mouse LTA Protein Pre-coupled Magnetic Beads HEK293
Mouse Lta-90M Mouse Tumour Necrosis Factor alpha (rDNA derived) Reference standard N/A
Mouse LTA-5234M Recombinant Mouse LTA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Lta-1346M Recombinant Mouse Lta Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Lta-4368M Recombinant Mouse Lta protein, His-tagged E.coli His 34-202aa
Rat Lta-571R Recombinant Rat Lta protein, His-tagged E.coli His Ser35~Ser191
Rat LTA-3497R Recombinant Rat LTA Protein Mammalian Cell His
Rat Lta-440R Recombinant Rat Lta Protein, His-tagged E.coli N-His Leu34-Leu202
Rat LTA-3153R Recombinant Rat LTA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LTA-3153R-B Recombinant Rat LTA Protein Pre-coupled Magnetic Beads HEK293
Rabbit LTA-572R Recombinant Rabbit LTA protein, His & T7-tagged E.coli His/T7 Gly49~Ala194 (Accession # P10154)
Dog LTA-567D Recombinant Dog LTA protein, His-tagged E.coli His Leu66~Asp185 (Accession # Q5WR07)
Bacillus subtilis LTA-15B Native Bacillus subtilis LTA Protein
Rhesus Macaque LTA-2589R Recombinant Rhesus monkey LTA Protein, His-tagged Mammalian Cell His
Rhesus Macaque LTA-2409R Recombinant Rhesus Macaque LTA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LTA-2409R-B Recombinant Rhesus Macaque LTA Protein Pre-coupled Magnetic Beads HEK293
S. aureus LTA-18S Native S. aureus LTA Protein
S. aureus LTA-14S Native S. aureus LTA Protein
Zebrafish LTA-3065Z Recombinant Zebrafish LTA Mammalian Cell His
Pig LTA-570P Recombinant Pig LTA protein, His & T7-tagged E.coli His/T7 Lys53~Phe172 (Accession # P26445)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LTA Related Articles
  • LTA Related Signal Pathway

LTA involved in several pathways and played different roles in them. We selected most pathways LTA participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LTA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTHPO;PRLRA;LOC100033925;IFNPHI1;CCL3L3;IL10RB;IFNE;IFNL3;IL3
NF-kappa B signaling pathwayPRKCB;RIPK1;LTBR;TRADD;PTGS2;ZAP70;BCL10;XIAP;GM1987
TNF signaling pathwayFOS;PIK3CG;ICAM1;PTGS2;LTA;MAPK3;MMP14;MAP2K3;MAP2K7
Type I diabetes mellitusHLA-DMA;HLA-F;FAS;HLA-DQA1;HSPD1;HLA-E;GAD1;HLA-DOA;IL12B
HTLV-I infectionFZD5;NFATC4;GM-CSF;WNT10B;CD3E; CD3D;IKBKG;WNT9B;WNT2B;MYBL1
Herpes simplex infectionIFNAR2;C5;MHC1UEA;TNFRSF14;SRSF9;Hc;MHC1UXA2;PPP1CAA;NFKBIAA

LTA has several biochemical functions, for example, cytokine activity, receptor binding, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LTA itself. We selected most functions LTA had, and list some proteins which have the same functions with LTA. You can find most of the proteins on our site.

Function Related Protein
cytokine activityIFNA12;IL29;BMP5;IFNA16;Fasl;IL33;Cxcl15;GDF7;CMTM2
receptor bindingSERPINE2;SEMA4D;FGF13A;ANGPTL2;P2RX7;DDX54;SLC27A2;TNFSF14;TMEM38A
tumor necrosis factor receptor bindingFasl;TNFSF13;TRAF4;TNFSF8;TRADD;LTA;TNFSF10L3;EDA;ERAP1

LTA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LTA here. Most of them are supplied by our site. Hope this information will be useful for your research of LTA.

LGALS2; TUBA1A; TNFRSF14; BIRC2; RIPK1

Leroux-Kozal, V; Leveque, N; et al. Merkel cell carcinoma: histopathologic and prognostic features according to the immunohistochemical expression of Merkel cell polyomavirus large T antigen correlated with viral load. HUMAN PATHOLOGY 46:443-453(2015).
Dammermann, W; Bochmann, D; et al. CMV specific cytokine release assay in whole blood is optimized by combining synthetic CMV peptides and toll like receptor agonists. JOURNAL OF IMMUNOLOGICAL METHODS 414:82-90(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
What are some potential therapeutic applications of LTA protein? 02/21/2023

LTA protein is being investigated for its potential use in cancer therapy, autoimmune diseases, and infectious diseases.

Are there any clinical trials involving LTA protein? 06/22/2022

Clinical trials may have been initiated to investigate the therapeutic potential of LTA protein since my last update. It's advisable to check the latest information.

What are some potential side effects or adverse reactions associated with LTA protein therapy? 03/19/2021

Potential side effects may include immune-related adverse events, such as inflammation and cytokine release syndrome.

Can LTA protein be used to treat autoimmune diseases? 08/11/2018

LTA protein has been studied for its potential to modulate autoimmune responses, but more research is needed.

Can LTA protein be used in cancer treatment? 04/05/2017

LTA protein has shown potential in cancer immunotherapy by targeting and destroying cancer cells.

Customer Reviews (3)

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Reviews
04/14/2020

    Its purity, integrity, and functionality are ensured through stringent quality control measures, which instills confidence in the reliability and accuracy of my research results.

    01/03/2020

      Their technical expertise, product quality, customer support, and supply management collectively contribute to the success and progress of my trials.

      08/24/2017

        The manufacturer also offers valuable customer support, actively aiding researchers in their experimental journey.

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