Lypla1
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Official Full Name
lysophospholipase I
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Overview
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. -
Synonyms
LYPLA1; lysophospholipase I; acyl-protein thioesterase 1; Acyl protein thioesterase 1; APT 1; APT1; LPL1; LYPLA 1; LYSOPLA; LPL-I; lysoPLA I; lysophospholipase 1; acyl-protein thioesterase-1; lysophospholipid-specific lysophospholipase; APT-1; hAPT1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E. coli
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Lypla1 Related Articles
Lypla1 involved in several pathways and played different roles in them. We selected most pathways Lypla1 participated on our site, such as Choline metabolism in cancer, Glycerophospholipid metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Lypla1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Choline metabolism in cancer | NRAS;PLD2;PIK3CA;PIK3CG;GPCPD1;SLC22A3;PIK3R5;RHEB;EIF4EBP1 |
| Glycerophospholipid metabolism | PCYT1BB;STIL;CHAT;PNPLA7;GPD1B;PPAP2A;AGXT2L1;DGKE;PLA2G5 |
| Metabolism | SLC25A10;CYP2A7;COX7C;ADSL;LPA;KCNB1;APOC2;TREH;UROC1 |
| Metabolism of nitric oxide | NOSTRIN;DDAH1;CYGB2;CYGB1;DDAH2;CYGB;ZDHHC21;LYPLA1;NOSIP |
| eNOS activation | DDAH2;CYGB;CYGB1;DDAH1;ZDHHC21;LYPLA1;CYGB2 |
| eNOS activation and regulation | ZDHHC21;LYPLA1;DDAH1;CYGB1;SPRB;DDAH2;CYGB2;NOSIP;CYGB |
Lypla1 has several biochemical functions, for example, lipase activity, lysophospholipase activity, palmitoyl-(protein) hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Lypla1 itself. We selected most functions Lypla1 had, and list some proteins which have the same functions with Lypla1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipase activity | PNPLA7;NOTUM1A;DAGLB;ABHD2A;LIPA;AADAC;LIPM;CES1C;CELL |
| lysophospholipase activity | PLA2G4B;PLA2G4A;PNPLA6;LYPLAL1;Cel;ENPP2;MGLL;LYPLA1;LGALS13 |
| palmitoyl-(protein) hydrolase activity | LYPLA2;PPT1;LYPLAL1;LYPLA1;PPT2 |
Lypla1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Lypla1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Lypla1.
VHL; IKBKE; NS; VCAM1
- Q&As
- Reviews
Q&As (7)
Ask a questionGenetic mutations in LYPLA1 can lead to dysregulation of lipid metabolism and protein modification.
Altered LYPLA1 activity is linked to various diseases, including metabolic and neurodegenerative disorders.
Targeting LYPLA1 could provide new strategies for treating diseases related to lipid metabolism and protein modification.
LYPLA1 works with other lipid metabolism enzymes, coordinating lipid modification and signaling pathways.
LYPLA1, a lysophospholipase, is involved in lipid metabolism, crucial for maintaining cellular lipid balance.
LYPLA1 is involved in signal transduction processes by modulating the lipidation status of signaling proteins.
It plays a role in protein modification, particularly in depalmitoylation, affecting protein function and localization.
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