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MAN2B1

  • Official Full Name

    mannosidase, alpha, class 2B, member 1

  • Overview

    This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    MAN2B1; mannosidase, alpha, class 2B, member 1; MANB; lysosomal alpha-mannosidase; LAMAN; EC 3.2.1.24; Lysosomal acid alpha mannosidase; Lysosomal alpha mannosidase; Mannosidase alpha class 2B member 1; Mannosidase, alpha B; Mannosidase, alpha B, lysosomal; mannosidase alpha-B; lysosomal acid alpha-mannosidase;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAN2B1-4524HCL Recombinant Human MAN2B1 293 Cell Lysate HEK293 N/A
Human MAN2B1-4289H Recombinant Human MAN2B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAN2B1-1550H Recombinant Human MAN2B1 protein, His & T7-tagged E.coli His/T7 Ala883~Gly1011 (Accession # O00754)
Human MAN2B1-2719H Recombinant Human MAN2B1 protein, His-tagged E.coli His 51-342 aa
Mouse MAN2B1-9486M Recombinant Mouse MAN2B1 Protein Mammalian Cell His
Mouse Man2b1-3914M Recombinant Mouse Man2b1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAN2B1-5316M Recombinant Mouse MAN2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAN2B1-5316M-B Recombinant Mouse MAN2B1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAN2B1-2257Z Recombinant Zebrafish MAN2B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAN2B1 Related Articles

MAN2B1 involved in several pathways and played different roles in them. We selected most pathways MAN2B1 participated on our site, such as Other glycan degradation, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAN2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Other glycan degradationAGA;ENG-1;ENGASE;HEXDC;HEXA;GBA;GLB1;NEU3.3;FUCA1.1
LysosomeCD164;ATP6V0D1;ENTPD4;ATP6V0A1A;AP1S3B;LAMP2;LAMP1;AP1G2;HEXA

MAN2B1 has several biochemical functions, for example, alpha-mannosidase activity, mannose binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAN2B1 itself. We selected most functions MAN2B1 had, and list some proteins which have the same functions with MAN2B1. You can find most of the proteins on our site.

Function Related Protein
alpha-mannosidase activityMAN2B2;MAN2B1;MAN2A2;MAN2C1
mannose bindingCD209;CLN5;M6PR;CD207;CD209C;COLEC10;CD209A;MRC1;MBL2
zinc ion bindingPCGF5A;ARIH2;PHF14;AGTPBP1;DPEP1;CXXC1;PCGF3;TRIM22;RNF125

MAN2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAN2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAN2B1.

L2; L2; cona_canen

Natiq, A; Elalaoui, SC; et al. A new case of de novo 19p13.2p13.12 deletion in a girl with overgrowth and severe developmental delay. MOLECULAR CYTOGENETICS 7:-(2014).
Wu, XY; Pan, JX; et al. Molecular diagnosis of a Chinese pedigree with alpha-mannosidosis and identification of a novel missense mutation. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 27:491-495(2014).
  • Q&As
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