MARCKS
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Official Full Name
myristoylated alanine-rich protein kinase C substrate
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Overview
Myristoylated alanine-rich C-kinase substrate (MARCKS) is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. -
Synonyms
MARCKS; myristoylated alanine-rich protein kinase C substrate; MACS, myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L); myristoylated alanine-rich C-kinase substrate; 80K L; PKCSL; phosphomyristin; protein kinase C substrate, 80 kDa protein, light chain; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); MACS; 80K-L; PRKCSL; FLJ14368; FLJ90045;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Chicken
- Human
- Mouse
- Bovine brain
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- MARCKS Related Articles
MARCKS involved in several pathways and played different roles in them. We selected most pathways MARCKS participated on our site, such as Fc gamma R-mediated phagocytosis, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Fc gamma R-mediated phagocytosis | PRKCG;MARCKS;SPHK1;PLD1;WASF3;PLA2G6;PIK3CG;MARCKSL1;GSN |
MicroRNAs in cancer | HNRNPK;ITGA5;ROCK1;SLC45A3;IGF2BP1;MDM2;TNC;APC;PRKCB |
MARCKS has several biochemical functions, for example, actin filament binding, calmodulin binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCKS itself. We selected most functions MARCKS had, and list some proteins which have the same functions with MARCKS. You can find most of the proteins on our site.
Function | Related Protein |
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actin filament binding | CTNNAL1;TRIOBPB;MYH9;ANXA8;VCLA;SMYHC2;SHROOM3;MYO7A;MYO10 |
calmodulin binding | RGS2;PHKG1B;GAP43;AKAP5;CAMK2D1;C2orf62;PHKB;SNTB2;MARCKSL1B |
protein kinase C binding | TRPV4;AVPR1B;MARCKS;DSP;CASQ2;PEA15A;DACT1;HAND2;C1QBP |
MARCKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCKS here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCKS.
CNOT8; TRAF6; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ssrna_ug; MAPK13; PTBP3; cona_canen; NS; ATF2; polg_hcvh
- Q&As
- Reviews
Q&As (5)
Ask a questionMARCKS is involved in synaptic function and may contribute to the synaptic dysfunction observed in Alzheimer's disease.
Yes, MARCKS is involved in inflammatory processes, and its dysregulation may contribute to inflammatory diseases.
Yes, MARCKS has been linked to neurological disorders, and its dysregulation may contribute to conditions such as Alzheimer's disease.
Yes, MARCKS is a potential target for drug development, particularly in conditions where its dysregulation contributes to disease progression.
Modulating MARCKS expression or activity may be considered as a therapeutic approach for certain cardiovascular conditions.
Customer Reviews (3)
Write a reviewMARCKS protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.
researchers have found MARCKS protein to be highly suitable for protein electron microscopy structure analysis.
MARCKS protein is highly recommended for research applications, particularly in ELISA assays and protein electron microscopy structure analysis.
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