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MARCKS

  • Official Full Name

    myristoylated alanine-rich protein kinase C substrate

  • Overview

    Myristoylated alanine-rich C-kinase substrate (MARCKS) is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.
  • Synonyms

    MARCKS; myristoylated alanine-rich protein kinase C substrate; MACS, myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L); myristoylated alanine-rich C-kinase substrate; 80K L; PKCSL; phosphomyristin; protein kinase C substrate, 80 kDa protein, light chain; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); MACS; 80K-L; PRKCSL; FLJ14368; FLJ90045;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Bovine brain
  • E.coli
  • HEK293
  • HEK293T
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MARCKS-16H Recombinant Human MARCKS protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MARCKS-17H Recombinant Human MARCKS protein, GST-tagged Wheat Germ GST
Human MARCKS-1097H Recombinant Human MARCKS Protein, His&SUMO-tagged E.coli N-His&SUMO Gly2-Glu332
Human MARCKS-1369H Recombinant Human MARCKS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MARCKS-5590HFL Recombinant Full Length Human MARCKS protein, Flag-tagged Mamanlian cells Flag
Human MARCKS-395HFL Active Recombinant Full Length Human MARCKS Protein, C-Flag-tagged Mammalian cells Flag
Human MARCKS-1369H-B Recombinant Human MARCKS Protein Pre-coupled Magnetic Beads HEK293
Human MARCKS-4482H Recombinant Human MARCKS Protein (Met1-Glu332), N-His tagged E.coli N-His Met1-Glu332
Mouse MARCKS-9563M Recombinant Mouse MARCKS Protein Mammalian Cell His
Mouse MARCKS-5370M Recombinant Mouse MARCKS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Marcks-3959M Recombinant Mouse Marcks Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MARCKS-5370M-B Recombinant Mouse MARCKS Protein Pre-coupled Magnetic Beads HEK293
Bovine MARCKS-12B Native Bovine MARCKS protein Bovine brain N/A
Chicken MARCKS-7029C Recombinant Chicken MARCKS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MARCKS Related Articles

MARCKS involved in several pathways and played different roles in them. We selected most pathways MARCKS participated on our site, such as Fc gamma R-mediated phagocytosis, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARCKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fc gamma R-mediated phagocytosisPRKCG;MARCKS;SPHK1;PLD1;WASF3;PLA2G6;PIK3CG;MARCKSL1;GSN
MicroRNAs in cancerHNRNPK;ITGA5;ROCK1;SLC45A3;IGF2BP1;MDM2;TNC;APC;PRKCB

MARCKS has several biochemical functions, for example, actin filament binding, calmodulin binding, protein kinase C binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARCKS itself. We selected most functions MARCKS had, and list some proteins which have the same functions with MARCKS. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingCTNNAL1;TRIOBPB;MYH9;ANXA8;VCLA;SMYHC2;SHROOM3;MYO7A;MYO10
calmodulin bindingRGS2;PHKG1B;GAP43;AKAP5;CAMK2D1;C2orf62;PHKB;SNTB2;MARCKSL1B
protein kinase C bindingTRPV4;AVPR1B;MARCKS;DSP;CASQ2;PEA15A;DACT1;HAND2;C1QBP

MARCKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARCKS here. Most of them are supplied by our site. Hope this information will be useful for your research of MARCKS.

CNOT8; TRAF6; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; ssrna_ug; MAPK13; PTBP3; cona_canen; NS; ATF2; polg_hcvh

Tinoco, LW; Fraga, JL; et al. Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:837-849(2014).
Contreras-Vallejos, E; Utreras, E; et al. Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(-/-) Mice. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does MARCKS impact neurodegenerative diseases like Alzheimer's? 10/15/2021

MARCKS is involved in synaptic function and may contribute to the synaptic dysfunction observed in Alzheimer's disease.

Is MARCKS associated with inflammation? 03/10/2021

Yes, MARCKS is involved in inflammatory processes, and its dysregulation may contribute to inflammatory diseases.

Is MARCKS protein associated with neurological disorders? 01/02/2018

Yes, MARCKS has been linked to neurological disorders, and its dysregulation may contribute to conditions such as Alzheimer's disease.

Can MARCKS be a target for drug development? 07/17/2017

Yes, MARCKS is a potential target for drug development, particularly in conditions where its dysregulation contributes to disease progression.

Can targeting MARCKS be a strategy for cardiovascular disease treatment? 06/07/2017

Modulating MARCKS expression or activity may be considered as a therapeutic approach for certain cardiovascular conditions.

Customer Reviews (3)

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Reviews
07/21/2022

    MARCKS protein's ability to maintain structural integrity during imaging facilitates the detailed visualization of protein complexes and their interactions.

    03/23/2022

      researchers have found MARCKS protein to be highly suitable for protein electron microscopy structure analysis.

      12/27/2021

        MARCKS protein is highly recommended for research applications, particularly in ELISA assays and protein electron microscopy structure analysis.

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