marco
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  • Official Full Name
  • macrophage receptor with collagenous structure
  • Background
  • Macrophage receptor MARCO is a protein that in humans is encoded by the MARCO gene. The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an intracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.
  • Synonyms
  • MARCO; SCARA2; Macrophage receptor MARCO; Macrophage receptor with collagenous structure; MARCO_HUMAN; Scavenger receptor class A member 2
Cat.#:MARCO-5940HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human MARCO protein, His-tagged
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Cat.#:MARCO-750HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MARCO, His-tagged
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Cat.#:Marco-2229MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Marco, His tagged
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Cat.#:Marco-589MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Marco protein, His-tagged
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Cat.#:Marco-7944MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Marco protein, His & T7-tagged
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Cat.#:Marco-7945RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Marco protein, His & T7-tagged
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Cat.#:MARCO-6301CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MARCO
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Cat.#:MARCO-2563MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MARCO cell lysate
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Involved Pathway

Marco involved in several pathways and played different roles in them. We selected most pathways Marco participated on our site, such as Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Marco were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
ATP6V0E2; MHC2DAB; MBL1; STX7; HLA-B; TUBB2B; TUBA7L; HLA-DRB4; HBL4; C1RA

Protein Function

Marco has several biochemical functions, for example, scavenger receptor activity, signaling pattern recognition receptor activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Marco itself. We selected most functions Marco had, and list some proteins which have the same functions with Marco. You can find most of the proteins on our site.
Function
Related Protein
Function scavenger receptor activity
Related Protein PGBD1; TMPRSS2; LOXL3; TINAGL1; CD5L; POLR1B; TMPRSS4; TMPRSS13B; CXCR7; CFI
Function signaling pattern recognition receptor activity
Related Protein DMBT1; CLEC7A; COLEC12; TLR2; MARCO; TRIM5; FCN1
Function transmembrane signaling receptor activity
Related Protein KLRC1; NFAM1; CD27; EDAR; OR2A4; FZD7A; GHRHRA; CD247; M6PR; EGFR

Interacting Protein

Marco has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Marco here. Most of them are supplied by our site. Hope this information will be useful for your research of Marco.
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Marco Related Articles

Verschoor, CP; Dorrington, MG; et al. MicroRNA-155 Is Required for Clearance of Streptococcus pneumoniae from the Nasopharynx. INFECTION AND IMMUNITY 82:4824-4833(2014).
Majumder, PP; Sarkar-Roy, N; et al. Genomic correlates of variability in immune response to an oral cholera vaccine. EUROPEAN JOURNAL OF HUMAN GENETICS 21:1000-1006(2013).