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MAX

  • Official Full Name

    MYC associated factor X

  • Overview

    The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
  • Synonyms

    MAX; MYC associated factor X; bHLHd4; protein max; class D basic helix-loop-helix protein 4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAX-2506H Active Recombinant Human MYC Associated Factor X, Flag-tagged E.coli Flag
Human MAX-2365H Recombinant Human MYC Associated Factor X, His-tagged E.coli His
Human MAX-7342H Recombinant Human MAX protein, His&GST-tagged Insect Cells His/GST Met1-Ser160
Human MAX-28524TH Recombinant Human MAX, FLAG-tagged E.coli Flag
Human MAX-177H Recombinant Human MAX protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAX-176H Recombinant Human MAX protein, GST-tagged Wheat Germ GST
Human MAX-28862TH Recombinant Human MAX, His-tagged E.coli His
Human MAX-171H Recombinant Human MAX protein, His-tagged E.coli His
Human MAX-174H Recombinant Human MAX protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAX-172H Recombinant Human MAX protein, His-tagged E.coli His
Human MAX-173H Recombinant Human MAX protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAX-407HCL Recombinant Human MAX cell lysate Insect Cell N/A
Human MAX-4407HFL Recombinant Full Length Human MAX protein, Flag-tagged Mamanlian cells Flag
Human MAX-1547H Recombinant Human MAX protein, His & GST-tagged E.coli His/GST Ser2~Ser160 (Accession # P61244)
Human MAX-3511H Recombinant Human MAX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAX-5911H Recombinant Human MAX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAX-4501H Recombinant Human MAX Protein (Met1-Ser151), C-His tagged E.coli C-His Met1-Ser151
Human MAX-4077HFL Recombinant Full Length Human MAZ protein, Flag-tagged Mamanlian cells Flag
Human MAX-4503H Recombinant Human MAX Protein (Ser2-Ser160), N-GST tagged E.coli N-GST Ser2-Ser160
Mouse Max-3975M Recombinant Mouse Max Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat MAX-3600R Recombinant Rat MAX Protein Mammalian Cell His
Rat MAX-3256R Recombinant Rat MAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAX-3256R-B Recombinant Rat MAX Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAX-2690R Recombinant Rhesus monkey MAX Protein, His-tagged Mammalian Cell His
Rhesus Macaque MAX-2510R-B Recombinant Rhesus Macaque MAX Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MAX-2510R Recombinant Rhesus Macaque MAX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MAX-8821Z Recombinant Zebrafish MAX Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAX Related Articles
  • MAX Related Research Area

MAX involved in several pathways and played different roles in them. We selected most pathways MAX participated on our site, such as MAPK signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPP3R2;PDGFAB;RAC3A;TP53;NFATC3;ARR3A;FGF21;FGF10A;Casp3
Pathways in cancerPLD1;VEGFB;WNT6;IKBKB;MAPK1;NTRK1;PTGER3;SMAD2;MMP9
Transcriptional misregulation in cancerBCL2A1;H3F3A;MYCN;ZEB1;TRP53;CLSTN2;HPGD;GOLPH3;SIX4
Small cell lung cancerRARB;LAMA1;BIRC7;CCNE2;ITGB1;BIRC3;COL4A1;BCL2;XIAP

MAX has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAX itself. We selected most functions MAX had, and list some proteins which have the same functions with MAX. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFOSL1A;GLI2;ELK1;FOS;TBX20;ZNF114;GRHL1;KLF13;ETV1
protein bindingNOTCH2NL;MCCC1;HNRNPUL1;PGLS;CNOT2;BLOC1S2A;ITSN1;SPSB4;ALDH3B1
protein dimerization activityARNTL1B;TFE3B;MYCL1;TWIST1A;AIFM1;ATOH1;HER11;BTRC;MSGN1
transcription coactivator activitySUPT7L;SMARCB1;GABPA;MED16;NCOA1;WWTR1;KLF7;JUN;GTF2A1
transcription cofactor activityKAT2B;ELK4;PTPN14;TADA2A;ZFP865;NFE2L1;PHF21B;TFDP2;MSX2
transcription factor activity, RNA polymerase II core promoter sequence-specificHEYL;PAX7;HEY2;TFAP2B;MEF2C;HEY1;NKX3;SMAD3;MAX
transcription factor activity, sequence-specific DNA bindingKDM5B;ZC3H8;SUPT6H;LHX1A;ETV5A;FOXG1;TADA2B;POU1F1;RELA

MAX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAX here. Most of them are supplied by our site. Hope this information will be useful for your research of MAX.

MYC

Soleri, R; Demey, H; et al. Peptide conjugated chitosan foam as a novel approach for capture-purification and rapid detection of hapten - Example of ochratoxin A. BIOSENSORS & BIOELECTRONICS 67:634-641(2015).
Henriksen, LT; Harila-Saari, A; et al. PEG-Asparaginase Allergy in Children With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Protocol. PEDIATRIC BLOOD & CANCER 62:427-433(2015).
  • Q&As
  • Reviews

Q&As (6)

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How to evaluate the potential of MAX proteins as drug targets? 07/16/2022

Evaluating the potential of MAX proteins as drug targets can involve several aspects, including their expression levels in organisms, their role in biological processes, and their changes in disease. In addition, factors such as ease of drug development for this protein and potential drug side effects need to be considered.

What is the function of MAX proteins? 02/05/2022

The function of MAX proteins may be related to their localization and structure within the cell. It may be a nuclear protein that regulates the transcription of specific genes by binding to DNA. In addition, it may also regulate processes such as cell signaling and cell proliferation by interacting with other proteins.

What are the effects of mutations or modifications in MAX proteins on organisms? 12/04/2020

Mutations or modifications of MAX proteins may affect their function and thus on the organism. The specific effects may vary depending on the type and location of the mutation or modification and may involve various biological processes, such as growth and development, immune response, etc.

What biological processes does MAX protein play a role in? 11/26/2020

MAX proteins may be involved in a variety of biological processes, including cell proliferation, cell differentiation, apoptosis, etc. It may influence tumorigenesis and progression by modulating these processes.

How is the expression level of MAX protein regulated? 10/06/2020

The expression level of MAX protein may be regulated by a variety of factors, including gene transcription, translation, post-transcriptional modification, etc. Studying these regulatory mechanisms can help to understand the expression patterns of MAX proteins in organisms and their effects on biological processes.

How does MAX protein interact with other proteins? 05/28/2020

MAX proteins may interact with other proteins to fulfill their functions. These interactions can involve various types of protein-protein interactions like electrostatic interactions, hydrogen bonding, etc. Understanding these interactions can help uncover the mechanism of action of MAX proteins in cells.

Customer Reviews (3)

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Reviews
07/16/2023

    Greatly improve the rate and selectivity of chemical reactions, and its scientific research value is incomparable.

    05/14/2023

      MAX has excellent labeling results and can be used for a wide range of experimental methods, such as fluorescent labeling.

      06/11/2021

        The high catalytic efficiency, high safety, and high expression level make the experimental results extremely confident.

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