mccc2
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  • Official Full Name
  • methylcrotonoyl-CoA carboxylase 2 (beta)
  • Background
  • This gene encodes the small subunit of3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, anautosomal recessive disorder of leucine catabolism.
  • Synonyms
  • MCCC2; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl Coenzyme A carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCB; biotin carboxylase; MCCase subunit beta; 3-methylcrotonyl-CoA carboxylase 2; methylcrotonoyl
Cat.#:MCCC2-8174HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MCCC2 protein, His & T7-tagged
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Cat.#:Mccc2-8175MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mccc2 protein, His & T7-tagged
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Cat.#:MCCC2-3615RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MCCC2 Protein
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Cat.#:MCCC2-12180ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MCCC2
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Cat.#:MCCC2-4428HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MCCC2 293 Cell Lysate
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Involved Pathway

MCCC2 involved in several pathways and played different roles in them. We selected most pathways MCCC2 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Valine, leucine and isoleucine degradation
HIBADH; MCEE; ALDH1B1; OXCT1; PCCB; DLDH; ALDH6A1; ACAA1; HMGCLL1; AACS
Metabolic pathways
PIGYL; GOT2B; MCAT; POLR1A; UGT8; POLR2B; CS; G6PC2; GALNT18; UQCRQ

Protein Function

MCCC2 has several biochemical functions, for example, ATP binding, methylcrotonoyl-CoA carboxylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC2 itself. We selected most functions MCCC2 had, and list some proteins which have the same functions with MCCC2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCC10; TAOK2; NMRK1; ACSM5; EARS2; ACOT12; C9orf96; ACTC1A; ATP6V1B2; RAD51L3
Function methylcrotonoyl-CoA carboxylase activity
Related Protein MCCC2; MCCC1
Function protein binding
Related Protein ZBTB17; RAB8B; CAV1; CTPS2; PFDN4; SH3BP2; CAMKK1; DTNB; PIK3CB; HMOX2

Interacting Protein

MCCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC2.
INPPL1; US11; IFIT1; b14_vaccw; EPS15; GABARAPL2; k7_vaccw; STK4; ICT1; UBASH3B; HDAC11; ECSIT; MAP1LC3A; SIRT4

MCCC2 Related Articles

Hwu, WL; Suzuki, Y; et al. Late-onset holocarboxylase synthetase deficiency with homologous R508W mutation. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 99:174-177(2000).