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MCCC2

Official Full Name

methylcrotonoyl-CoA carboxylase 2 (beta)
Overview

This gene encodes the small subunit of3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, anautosomal recessive disorder of leucine catabolism.
Synonyms

MCCC2; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl Coenzyme A carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; MCCB; biotin carboxylase; MCCase subunit beta; 3-methylcrotonyl-CoA carboxylase 2; methylcrotonoyl;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

C
Myc
DDK
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCCC2-8174H	Recombinant Human MCCC2 protein, His & T7-tagged	E.coli	His/T7	Arg337~Met563 (Accession # Q9HCC0)	Inquiry
Human	MCCC2-4428HCL	Recombinant Human MCCC2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MCCC2-189H	Recombinant Human MCCC2 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Mouse	Mccc2-8175M	Recombinant Mouse Mccc2 protein, His & T7-tagged	E.coli	His/T7	Ser380~Met563 (Accession # B2RUK5)	Inquiry
Mouse	Mccc2-3991M	Recombinant Mouse Mccc2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	MCCC2-3615R	Recombinant Rat MCCC2 Protein	Mammalian Cell	His		Inquiry
Rat	MCCC2-3271R	Recombinant Rat MCCC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MCCC2-3271R-B	Recombinant Rat MCCC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MCCC2-12180Z	Recombinant Zebrafish MCCC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MCCC2 Related Articles

MCCC2 involved in several pathways and played different roles in them. We selected most pathways MCCC2 participated on our site, such as Valine, leucine and isoleucine degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCCC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Valine, leucine and isoleucine degradation	ALDH2;HMGCL;ALDH3A2A;ALDH2.2;OXCT1B;BCAT2;ALDH9A1A.1;OXCT2;HADHAA
Metabolic pathways	GCNT4;NT5C1B;PTGDS;ACADM;ATP6V1H;SGMS1;TAT;RDH10B;PANK1

MCCC2 has several biochemical functions, for example, ATP binding, methylcrotonoyl-CoA carboxylase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCCC2 itself. We selected most functions MCCC2 had, and list some proteins which have the same functions with MCCC2. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	NLRC3;ULK4;ZRANB3;ROCK2;PAPSS1;PIK3CA;UCK2;PRPS2;OAS3
methylcrotonoyl-CoA carboxylase activity	MCCC1;MCCC2
protein binding	CHGB;CD70;ACE2;CD200R3;XRCC3;ARHGEF16;A2M;Pilrb1;MDFIC

MCCC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCCC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCCC2.

INPPL1; US11; IFIT1; b14_vaccw; EPS15; GABARAPL2; k7_vaccw; STK4; ICT1; UBASH3B; HDAC11; ECSIT; MAP1LC3A; SIRT4

Hwu, WL; Suzuki, Y; et al. Late-onset holocarboxylase synthetase deficiency with homologous R508W mutation. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 99:174-177(2000).