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MCEE

Official Full Name

methylmalonyl CoA epimerase
Overview

The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria.
Synonyms

MCEE; methylmalonyl CoA epimerase; methylmalonyl-CoA epimerase, mitochondrial; GLOD2; glyoxalase domain containing 2; mitochondrial; DL methylmalonyl CoA racemase; DL-methylmalonyl-CoA racemase; EC 5.1.99.1; MCEE_HUMAN; METHYLMALONYL CoA RACEMASE; Methylmalonyl-CoA epimerase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells

Tag

C
His
His (Fc)
Avi
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCEE-29452TH	Recombinant Human MCEE, His-tagged	E.coli	His	140 amino acids	Inquiry
Human	MCEE-801H	Recombinant Human Methylmalonyl CoA Epimerase, His-tagged	E.coli	His		Inquiry
Human	MCEE-4426HCL	Recombinant Human MCEE 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MCEE-5211H	Recombinant Human MCEE Protein (Gln37-Ala176), N-His tagged	E.coli	N-His	Gln37-Ala176	Inquiry
Human	MCEE-5210H	Recombinant Human MCEE Protein (Gln37-Ala176), C-His tagged	Mammalian cells	C-His	Gln37-Ala176	Inquiry
Mouse	MCEE-9626M	Recombinant Mouse MCEE Protein	Mammalian Cell	His		Inquiry
Mouse	MCEE-5406M-B	Recombinant Mouse MCEE Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mcee-1734M	Recombinant Mouse Mcee protein, His & T7-tagged	E.coli	His/T7	Gln39~Ala178 (Accession # Q9D1I5)	Inquiry
Mouse	MCEE-5406M	Recombinant Mouse MCEE Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	Mcee-1735R	Recombinant Rat Mcee protein, His & T7-tagged	E.coli	His/T7	Gln39~Ala178 (Accession # D4A197)	Inquiry
Zebrafish	MCEE-2906Z	Recombinant Zebrafish MCEE	Mammalian Cell	His		Inquiry
Chicken	MCEE-5551C	Recombinant Chicken MCEE	Mammalian Cell	His		Inquiry
Chicken	MCEE-5550C	Recombinant Chicken MCEE	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MCEE Related Articles

MCEE involved in several pathways and played different roles in them. We selected most pathways MCEE participated on our site, such as Valine, leucine and isoleucine degradation, Glyoxylate and dicarboxylate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCEE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Valine, leucine and isoleucine degradation	HIBCH;BCKDHB;OXCT2B;HMGCLL1;MUT;ACAD8;AACS;ALDH9A1B;OXCT1
Glyoxylate and dicarboxylate metabolism	MUT;MDH2;GLULB;AGXTB;CS;MDH1AA;GRHPRB;DLDH;GCSHB
Propanoate metabolism	BCKDHB;ACADM;ackA;ECHDC1;SUCLG1;HADHA;ACAT1;HADHAA;MLYCD
Metabolic pathways	ALDH2.2;CRYL1;MINPP1B;UQCR11;AK7;PPT2;DLDH;POLR3B;PTDSS1A
Carbon metabolism	MTHFR;HKDC1;PKMB;PGAM1B;G6PDX;SDSL;ACADM;GPT;DLAT

MCEE has several biochemical functions, for example, metal ion binding, methylmalonyl-CoA epimerase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCEE itself. We selected most functions MCEE had, and list some proteins which have the same functions with MCEE. You can find most of the proteins on our site.

Function	Related Protein
metal ion binding	MAP3K4;ELP3;NT5C2L1;ZNF573;PAPOLG;SMPD3;TRAF4B;STAMBPL1;SCAPER
methylmalonyl-CoA epimerase activity
protein binding	LAMTOR1;MPP7;PRL;TRAM2;ASAP3;FKBP7;MAPRE2;FABP3;FBF1

MCEE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCEE here. Most of them are supplied by our site. Hope this information will be useful for your research of MCEE.

AGTRAP; CMTM5

Guan, NZ; Shin, HD; et al. Understanding of how Propionibacterium acidipropionici respond to propionic acid stress at the level of proteomics. SCIENTIFIC REPORTS 4:-(2014).

Depuydt, G; Xie, F; et al. LC-MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism. JOURNAL OF PROTEOME RESEARCH 13:1938-1956(2014).