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MCM10

  • Official Full Name

    minichromosome maintenance complex component 10

  • Overview

    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
  • Synonyms

    MCM10; minichromosome maintenance complex component 10; MCM10 minichromosome maintenance deficient 10 (S. cerevisiae); protein MCM10 homolog; CNA43; DNA43; PRO2249; FLJ31133; HsMCM10; MCM10 minichromosome maintenance deficient 10; MCM10_HUMAN; Minichromosome maintenance protein 10 isoform 1; homolog of yeast MCM10;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MCM10-4421HCL Recombinant Human MCM10 293 Cell Lysate HEK293 N/A
Mouse MCM10-9633M Recombinant Mouse MCM10 Protein Mammalian Cell His
Mouse MCM10-5409M Recombinant Mouse MCM10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MCM10-5409M-B Recombinant Mouse MCM10 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MCM10-3060Z Recombinant Zebrafish MCM10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MCM10 involved in several pathways and played different roles in them. We selected most pathways MCM10 participated on our site, such as Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of ATR in response to replication stressHUS1;MCM10;CLSPN;RAD1;RAD9A;DBF4;RAD9B;MCM8;RAD9
Activation of the pre-replicative complexCDK2;MCM8;DBF4;MCM10;CDT1
Cell CycleKIF2A;STAG2;CUL1;PDS5B;EP300;MAD2L2;LIN37;YWHABL;GADD45B
Cell Cycle CheckpointsTHRSP;HTATIP;BRE;RAD9;TP53BP1;HIST4H4;KAT5;RAD17;RAD50
Cell Cycle, MitoticDCTN1;MAPRE1B;ERCC6L;CEP57;POLD3;LMNB1;CENPC1;BORA;PHF8
DNA ReplicationRFC2;RPA4;RFC4;RNASEH2A;GMNN;MCM3L;CDT1;MCM4;rnhA
DNA Replication Pre-InitiationGMNN;CDT1;DBF4;MCM10

MCM10 has several biochemical functions, for example, DNA replication origin binding, double-stranded DNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM10 itself. We selected most functions MCM10 had, and list some proteins which have the same functions with MCM10. You can find most of the proteins on our site.

Function Related Protein
DNA replication origin bindingORC3L;ORC4;HSPD1;MCM2;CDC45;MCM10;ORC2L;ORC4L;MCM5
double-stranded DNA bindingMTERF2;RAD51D;HNRPDL;MEN1;ZNF638;DMC1;MTERF3;YBX1;HLF
identical protein bindingCLDN11;NFKBIA;FADD;SNCA;KCTD17;CAD;PRPF3;CEP72;RAD51
metal ion bindingACMSD;PFKM;ADH8B;SLC8A1;BNC2;TRIM8A;DCST1;FAM170A;GNAI1
protein bindingTUSC2;TAX1BP1;ATG5;MAP2K4;RBM10;SCARA5;PIKFYVE;VRK2;RND2
single-stranded DNA bindingSSBP1;IGHMBP2;CSDA;RAD51D;YBX1;MCM7;NEIL3;TDP1;OBFC1

MCM10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM10.

ORC2; MCM6; TRIM37; CDC7; ORC4; CDC45; CCND1; MCM3; CCND3; MCM7; CDKN1A; CDKN2A

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