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MCM8

  • Official Full Name

    minichromosome maintenance complex component 8

  • Overview

    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are;essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM;proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of;replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central;domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and;7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively;spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    MCM8; minichromosome maintenance complex component 8; C20orf154, chromosome 20 open reading frame 154; DNA replication licensing factor MCM8; dJ967N21.5; MGC4816; MGC12866; MGC119522; MGC119523; REC; REC homolog (Drosophila); REC homolog; minichromosome;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MCM8-782H Recombinant Human MCM8, GST-tagged E.coli GST C-term-356aa
Human MCM8-6085HF Recombinant Full Length Human MCM8 Protein, GST-tagged In Vitro Cell Free System GST 840 amino acids
Human MCM8-4516H Recombinant Human MCM8 Protein, GST-tagged Wheat Germ GST
Mouse MCM8-9641M Recombinant Mouse MCM8 Protein Mammalian Cell His
Mouse MCM8-5415M-B Recombinant Mouse MCM8 Protein Pre-coupled Magnetic Beads HEK293
Mouse MCM8-5415M Recombinant Mouse MCM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MCM8-3619R Recombinant Rat MCM8 Protein Mammalian Cell His
Rat MCM8-3275R Recombinant Rat MCM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MCM8-3275R-B Recombinant Rat MCM8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MCM8-2706R Recombinant Rhesus monkey MCM8 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MCM8-2526R-B Recombinant Rhesus Macaque MCM8 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MCM8-2526R Recombinant Rhesus Macaque MCM8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MCM8-5535C Recombinant Chicken MCM8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MCM8 involved in several pathways and played different roles in them. We selected most pathways MCM8 participated on our site, such as Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCM8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of ATR in response to replication stressCLSPN;RAD9;RAD9B;MCM10;MCM8;DBF4;HUS1;RAD17;CDK2
Activation of the pre-replicative complexDBF4;MCM8;CDT1;CDK2;MCM10
Assembly of the pre-replicative complexE2F3;GMNN;E2F2;E2F1;CDT1;MCM8
CDC6 association with the ORC:origin complexE2F3;MCM8;E2F2
CDT1 association with the CDC6:ORC:origin complexCDT1;MCM8;GMNN
Cell CycleSUN1;OFD1;NCAPD2;SDCCAG8;ZBTB17;CENPI;RAD9A;ITGB3BP;BARD1
Cell Cycle CheckpointsBRE;CDKN1B;KAT5;HIST4H4;CHEK2;CDK2;MCM8;CDK5RAP2;MCM10
Cell Cycle, MitoticTCTN2;NDE1;HIST3H2BB;TUBGCP4;GINS3;TUBGCP3;MCM8;MAU2;TUBB4B

MCM8 has several biochemical functions, for example, ATP binding, DNA binding, helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MCM8 itself. We selected most functions MCM8 had, and list some proteins which have the same functions with MCM8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNLRP12;ENTPD3;PIM1;DHX36;MET;ASNA1;NRK;CAMK1GB;UBE2R2
DNA bindingZBTB2;HOXA11B;SPI1B;KDM2AA;TCEB3B;MSXA;PPARD;DEDD;NR2C1
helicase activityHLTF;SMARCAD1;DHX37;SNRNP200;ACTG2;ERCC6L;TDRD9;EIF4A1;DDX11
protein bindingUBA2;HECTD3;MIEN1;PHOSPHO2-KLHL23;BCCIP;UCKL1;APOA2;PER3;HTR3A

MCM8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCM8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCM8.

MCMBP

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