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MCPH1

Official Full Name

MCPH1 microcephalin 1
Overview

MCPH1 looks like it might be a useful prognostic indicator in breast cancer associated with BRCA1 inactivation
Synonyms

MCPH1; microcephalin 1; microcephaly, primary autosomal recessive 1; microcephalin; BRCT repeat inhibitor of TERT expression 1; BRIT1; FLJ12847; BRCT-repeat inhibitor of TERT expression 1; MCT;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCPH1-4412HCL	Recombinant Human MCPH1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MCPH1-4512H	Recombinant Human MCPH1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MCPH1-6087HF	Recombinant Full Length Human MCPH1 Protein, GST-tagged	In Vitro Cell Free System	GST	610 amino acids	Inquiry
Mouse	MCPH1-9647M	Recombinant Mouse MCPH1 Protein	Mammalian Cell	His		Inquiry
Mouse	MCPH1-5420M-B	Recombinant Mouse MCPH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MCPH1-5420M	Recombinant Mouse MCPH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	MCPH1-3750C	Recombinant Chicken MCPH1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MCPH1 Related Articles

MCPH1 involved in several pathways and played different roles in them. We selected most pathways MCPH1 participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Condensation of Prophase Chromosomes, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCPH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell Cycle	AURKB;CCNH;CDC14AA;CCND1;CENPW;GMNN;ORC2L;ENSAA;MIS18BP1
Cell Cycle, Mitotic	POLD3;TOP2A;APITD1;ITGB3BP;CENPI;SDCCAG8;VRK1;CENPQ;ARPP19
Condensation of Prophase Chromosomes	SETB;SET;H3F3B.1;SMC2;PHF8;NCAPD3;MCPH1;NCAPG2;H3F3D
M Phase	CDCA8;RCC2;MAU2;PMF1;STAG2;ZWINT;ITGB3BP;GORASP2;MIS12
Mitotic Prophase	CTDNEP1A;SETA;NCAPG2;NEK6;NCAPH2;CNEP1R1;CTDNEP1;DULLARD;SMC4

MCPH1 has several biochemical functions, for example, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCPH1 itself. We selected most functions MCPH1 had, and list some proteins which have the same functions with MCPH1. You can find most of the proteins on our site.

Function	Related Protein
identical protein binding	CCL3;MPZL2B;ESYT2;SNX8;BIN1;IGF2R;TTN;COL1A2;TTC32
protein binding	SRSF11;SLPI;H2-KE2;OCIAD1;FAM127C;SLC6A4;POLR1A;GCNT1;PLK2

MCPH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCPH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCPH1.

E2F1; E2F2; KDM1A; TADA2A; ABCC2; PHF11; RNF8

Zhang, B; Wang, E; et al. Phosphorylation of the BRCA1C Terminus (BRCT) Repeat Inhibitor of hTERT (BRIT1) Protein Coordinates TopBP1 Protein Recruitment and Amplifies Ataxia Telangiectasia-mutated and Rad3-related (ATR) Signaling. JOURNAL OF BIOLOGICAL CHEMISTRY 289:34284-34295(2014).

Ishitobi, Y; Inoue, A; et al. Association of Microcephalin 1, Syntrophin-Beta 1, and Other Genes with Automatic Thoughts in the Japanese Population. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 165:492-501(2014).