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Mcpt1

Official Full Name

Mcpt1 mast cell protease 1
Overview

MCP-1 belongs to the family of chemotactic cytokines.MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than Chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL1, IL6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL3, IL5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4.
Synonyms

MCPT1; mast cell protease 1; MMCP-1; Mcp-1; AV080368;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Mouse	Mcpt1-306M	Recombinant Mouse Mcpt1, His tagged	Human Cell	His		$498 / 10 µg
Mouse	MCPT1-2749MCL	Recombinant Mouse MCPT1 cell lysate	Human Cell	N/A		Inquiry
Rat	MCPT1-2699R	Recombinant Rat MCPT1 Protein (21-260 aa), Myc-tagged	E.coli	Myc	21-260 aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein

Mcpt1 involved in several pathways and played different roles in them. We selected most pathways Mcpt1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Mcpt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

Mcpt1 has several biochemical functions, for example, hydrolase activity, peptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Mcpt1 itself. We selected most functions Mcpt1 had, and list some proteins which have the same functions with Mcpt1. You can find most of the proteins on our site.

Function	Related Protein
hydrolase activity	FAM108C;ATP9A;PPM1BA;ADAMTS7;CAPN12;SIRT3;G6PC3;LYZ1;CTSM
peptidase activity	OVCH2;Shh;ADAMTS4;CTSG;HTRA1B;USP43;AGBL4;ADAM1B;MCPT2
serine-type endopeptidase activity	TPP2;PREPL;PROC;GZMB;TMPRSS11B;OVCH2;HPR;CELA3A;TMPRSS12
serine-type peptidase activity	IRBP;TMPRSS4B;MCPT8;TRY;PRSS3;KLK1B16;PREP;DPP4;DPP7

Mcpt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Mcpt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Mcpt1.