mdh2
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  • Official Full Name
  • malate dehydrogenase 2, NAD (mitochondrial)
  • Background
  • Malate dehydrogenase (MDH) is a key enzyme in the tricarboxylic acid cycle and malate/aspartate shuttle. MDH is widely expressed in organisms from most bacteria to all eukaryotes. The cytoplasmic MDH isoenzyme (cMDH or MDH1) primarily reduces oxaloacetate
  • Synonyms
  • MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; MOR1; M-MDH; MGC:3559
Cat.#:MDH2-4498HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MDH2 Protein, GST-tagged
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Cat.#:MDH2-4499HTag:His
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MDH2 Protein, His-tagged
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Cat.#:MDH2-1093HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDH2
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Cat.#:MDH2-9664MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MDH2 Protein
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Cat.#:MDH2-3629RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MDH2 Protein
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Cat.#:MDH2-680CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MDH2 Protein, His-tagged
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Cat.#:MDH2-12349ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MDH2
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Cat.#:MDH2-2797HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MDH2, His-tagged
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Cat.#:MDH2-4407HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MDH2 293 Cell Lysate
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Cat.#:Kit-0545Tag:
Source (Host):Species:
Product nameMalate Dehydrogenase 2 Activity Assay Kit
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Involved Pathway

MDH2 involved in several pathways and played different roles in them. We selected most pathways MDH2 participated on our site, such as Citrate cycle (TCA cycle), Cysteine and methionine metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
ACLYA; PCXB; SUCLG2; IDH2; PDHA2; MDH1AA; DLAT; DLDH; OGDHA; ACLY
Cysteine and methionine metabolism
DNMT3; DNMT4; BCAT2; AHCY; CDO1; GCLM; TAT; AGXT2; GSS; LDHAL6A
Pyruvate metabolism
MDH1AA; GRHPR; FH1; GRHPRB; PDK2; PDK3; ACYP2; FH; ACSS2L; PCK2
Glyoxylate and dicarboxylate metabolism
MDH1; GCSHA; GRHPRA; GCSH; HAO1; ACAT2; GCSHB; AGXT; PCCA; GLUL
Metabolic pathways
HMGCRA; ATP5G1; AUH; ETNPPL; PYGM; SAT1; ACSL4A; LASS2; KLF15; MOGAT3
Carbon metabolism
ACAT1; PDHA1A; PKM; GPT2; OGDHA; AGXTA; ESD; HADHA; PKMA; RPIA

Protein Function

MDH2 has several biochemical functions, for example, L-malate dehydrogenase activity, malate dehydrogenase (NADP+) activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDH2 itself. We selected most functions MDH2 had, and list some proteins which have the same functions with MDH2. You can find most of the proteins on our site.
Function
Related Protein
Function L-malate dehydrogenase activity
Related Protein MDH2; MDH1; MDH1AA
Function malate dehydrogenase (NADP+) activity
Related Protein MDH2
Function poly(A) RNA binding
Related Protein MKRN2; UTP23; SF3A3; HNRNPK; SNRPD1; RPS26; MRPS30; UBFD1; HIST1H4D; SRP54B
Function protein self-association
Related Protein TRIM32; S100A7A; RSAD2; TRP53; TMEM190; CTSB; ZNF496; ZSWIM2; SVIP; PTH1R

Interacting Protein

MDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDH2.
VCAM1; PCNA; FHIT; WARS; ere_dna; MAPK13; GABARAP; FN1; NS; ATF2; GABARAPL2; GABARAPL1; MAP1LC3A