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MDM4

  • Official Full Name

    MDM4, p53 regulator

  • Overview

    This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latters degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]
  • Synonyms

    MDM4; MDM4, p53 regulator; HDMX; MDMX; MRP1; protein Mdm4; protein Mdmx; MDM4 protein variant G; MDM4 protein variant Y; MDM4-related protein 1; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; double minute 4, human homolog of; p53-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MDM4-194H Recombinant Human MDM4, His-tagged E.coli His
Human MDM4-27382TH Recombinant Human MDM4 Wheat Germ N/A 110 amino acids
Human MDM4-29757TH Recombinant Human MDM4 Wheat Germ N/A 490 amino acids
Human MDM4-4403HCL Recombinant Human MDM4 293 Cell Lysate HEK293 N/A
Human MDM4-302HF Recombinant Full Length Human MDM4 Protein In Vitro Cell Free System 490 amino acids
Human MDM4-30181H Recombinant Human MDM4 protein, GST-tagged E.coli GST Met1-Ser332
Human MDM4-6114HF Recombinant Full Length Human MDM4 Protein, GST-tagged In Vitro Cell Free System GST 490 amino acids
Human MDM4-4493H Recombinant Human MDM4 Protein, GST-tagged Wheat Germ GST
Human MDM4-0090H Recombinant Human MDM4 Protein (T2-A490), Tag Free E.coli No tag T2-A490
Human MDM4-4386H Recombinant Human MDM4 protein, His -tagged E.coli His 1-490aa
Human MDM4-0091H Recombinant Human MDM4 Protein (T2-A490), His tagged E.coli His T2-A490
Mouse MDM4-9668M Recombinant Mouse MDM4 Protein Mammalian Cell His
Mouse MDM4-5433M-B Recombinant Mouse MDM4 Protein Pre-coupled Magnetic Beads HEK293
Mouse MDM4-5433M Recombinant Mouse MDM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MDM4-3631R Recombinant Rat MDM4 Protein Mammalian Cell His
Rat MDM4-3287R Recombinant Rat MDM4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MDM4-3287R-B Recombinant Rat MDM4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MDM4-12004Z Recombinant Zebrafish MDM4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MDM4 Related Research Area

MDM4 involved in several pathways and played different roles in them. We selected most pathways MDM4 participated on our site, such as p signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
p signaling pathwayPTEN;CASP8;FAS;SERPINE1;CCNB2;RRM2;CASP9;SHISA5;Casp3
MicroRNAs in cancerNRAS;CYP24A1;EP300;PDGFA;TIMP3;RPS6KA5;NOTCH4;MAP2K1;SIRT1

MDM4 has several biochemical functions, for example, enzyme binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM4 itself. We selected most functions MDM4 had, and list some proteins which have the same functions with MDM4. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingBRCA1;KMT2E;AKIRIN2;CPSF1;GSTM3;CCND1;CTNNBL1;GOT2;SLC18A1
protein bindingSCYL3;SND1;FNBP4;MYPOP;STK39;ALDH18A1;FLCN;POLR2J;PPP2R5A
zinc ion bindingTRIM43C;PDZRN4;ADAMTS8;LMO4B;TCF19;LMX1A;SREK1IP1;CAR1;APOBEC3C

MDM4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM4.

TP53; MDM2

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