me3
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  • Official Full Name
  • malic enzyme 3, NADP(+)-dependent, mitochondrial
  • Background
  • Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
  • Synonyms
  • ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial; NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase; pyruvic-malic carboxylase; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3; NADP-ME; FLJ3
Cat.#:ME3-9673MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ME3 Protein
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Cat.#:ME3-5511ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ME3
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Cat.#:ME3-4399HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ME3 293 Cell Lysate
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Involved Pathway

ME3 involved in several pathways and played different roles in them. We selected most pathways ME3 participated on our site, such as Carbon metabolism, Metabolic pathways, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Carbon metabolism
ME1; FBP1A; DLST; IDH3B; EHHADH; SUCLA2; CPS1; HKDC1; PRPS1B; PSAT1
Metabolic pathways
CES1; UGP2A; B4GALT7; GRHPRA; GALNT4; ATP5A1; MAOA; PANK1B; RRM2; DCK
Pyruvate metabolism
PKMB; SLC16A8; PDP1; ALDH9A1B; ME1; ALDH9A1A.1; LDHAL6B; HAGHL; LDHBA; ALDH1B1

Protein Function

ME3 has several biochemical functions, for example, NAD binding, cofactor binding, malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ME3 itself. We selected most functions ME3 had, and list some proteins which have the same functions with ME3. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein MDH1; AOX1; IDH3G; ME3; IDH3A; GPD1L; GRHPR; PARP1; ME1; ME2
Function cofactor binding
Related Protein DAO; UROS; WWOX; C3; DDO; LMO2; HACL1; PGAM2; TYMS; TKT
Function malate dehydrogenase (decarboxylating) (NAD+) activity
Related Protein ME2; ME3; ME1
Function malate dehydrogenase (decarboxylating) (NADP+) activity
Related Protein ME3; ME1
Function malic enzyme activity
Related Protein MDH1; ME1; ME3; ME2
Function metal ion binding
Related Protein ADIPOR2; HSCB; ZNF143A; ZNF423; ITGB1BP3; ZNF576; CYP46A1.2; PHF23B; MT2; ZNF490
Function oxaloacetate decarboxylase activity
Related Protein ME1; ME3; FAHD1; ME2

ME3 Related Articles

Karimi-Aghcheh, R; Bok, JW; et al. Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator. G3-GENES GENOMES GENETICS 3:369-378(2013).
Barnetova, I; Vackova, I; et al. Dynamics of epigenetic remodeling in interspecies porcine zygotes. CZECH JOURNAL OF ANIMAL SCIENCE 57:83-94(2012).