Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

ME3

Official Full Name

malic enzyme 3, NADP(+)-dependent, mitochondrial
Overview

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Synonyms

ME3; malic enzyme 3, NADP(+)-dependent, mitochondrial; NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase; pyruvic-malic carboxylase; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3; NADP-ME; FLJ3;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

C
6×His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ME3-4399HCL	Recombinant Human ME3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ME3-2413H	Recombinant Human ME3 Protein (24-590 aa), His-tagged	E.coli	His	24-590 aa	Inquiry
Human	ME3-20H	Recombinant Human ME3 Protein, C-6×His tagged	E.coli	C-6×His		Inquiry
Human	ME3-42H	Recombinant Human ME3 Protein	E.coli			Inquiry
Human	ME3-22H	Recombinant Human ME3 Protein, His tagged	E.coli	His		$319 / 25ug
Mouse	ME3-9673M	Recombinant Mouse ME3 Protein	Mammalian Cell	His		Inquiry
Mouse	ME3-5437M	Recombinant Mouse ME3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ME3-5437M-B	Recombinant Mouse ME3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ME3-5511Z	Recombinant Zebrafish ME3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ME3 Related Articles

ME3 involved in several pathways and played different roles in them. We selected most pathways ME3 participated on our site, such as Carbon metabolism, Metabolic pathways, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ME3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Carbon metabolism	G6PDX;HAO1;PDHA1;TALDO1;SUCLA2;PGD;CPS1;PCXB;PKLR
Metabolic pathways	HMGCS2;MAT2A;NMRK1;PLD1A;PLA2G7;BCKDHB;AGMAT;DAK;ATP5B
Pyruvate metabolism	LDHBB;ALDH2.2;ME2;LDHBA;MDH2;LDHD;PDHA1B;LDHAL6B;SLC16A8

ME3 has several biochemical functions, for example, NAD binding, cofactor binding, malate dehydrogenase (decarboxylating) (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ME3 itself. We selected most functions ME3 had, and list some proteins which have the same functions with ME3. You can find most of the proteins on our site.

Function	Related Protein
NAD binding	GRHPR;CTBP2A;TESCA;HSD3B5;PHGDH;HADHA;GPD1;GLYR1;AOX4
cofactor binding	PAH;HIF1AN;ACLYA;PGAM2;PHYH;ACLY;HACL1;ME3;LMO2
malate dehydrogenase (decarboxylating) (NAD+) activity	ME3;ME1;ME2
malate dehydrogenase (decarboxylating) (NADP+) activity	ME1;ME3
malic enzyme activity	ME3;ME2;ME1;MDH1
metal ion binding	ZFP28;ADH1;TSHZ1;HRG;PPM1LA;CDK2;ZNF311;MMP14B;ATF2
oxaloacetate decarboxylase activity	FAHD1;ME3;ME1;ME2

ME3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ME3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ME3.

Karimi-Aghcheh, R; Bok, JW; et al. Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator. G3-GENES GENOMES GENETICS 3:369-378(2013).

Barnetova, I; Vackova, I; et al. Dynamics of epigenetic remodeling in interspecies porcine zygotes. CZECH JOURNAL OF ANIMAL SCIENCE 57:83-94(2012).