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MFN2

  • Official Full Name

    mitofusin 2

  • Overview

    Mitofusin 2 (MFN2) is an important transmembrane GTPase required for mitochondrial fusion. MFN2 has a role in the regulation of vascular smooth muscle cell proliferation. The protein is highly expressed in heart and skeletal muscle and ubiquitously expres
  • Synonyms

    MFN2; mitofusin 2; mitofusin-2; CMT2A2; CPRP1; KIAA0214; MARF; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor; HSG; CMT2A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In vitro E. coli expression system
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MFN2-36H Recombinant Human MFN2, MYC/DDK-tagged HEK293 Myc/DDK
Human MFN2-4347HCL Recombinant Human MFN2 293 Cell Lysate HEK293 N/A
Human MFN2-4380H Recombinant Human MFN2 Protein, GST-tagged Wheat Germ GST
Human MFN2-5029H Recombinant Human MFN2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MFN2-6685HFL Recombinant Full Length Human MFN2, Flag-tagged Mamanlian cells Flag
Human MFN2-1658HFL Recombinant Full Length Human MFN2 Protein, C-Flag-tagged Mammalian cells Flag
Human MFN2-2437H Recombinant Human MFN2 Protein, His-tagged E.coli N-His Met1-Lys316
Human MFN2-1406H Recombinant Human MFN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MFN2-103H Recombinant Human MFN2 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-757aa
Human MFN2-1406H-B Recombinant Human MFN2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mfn2-4058M Recombinant Mouse Mfn2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Homo sapiens (Human) RFL35851HF Recombinant Full Length Human Mitofusin-2(Mfn2) Protein, His-Tagged E.coli expression system His Full Length (1-757)
Mus musculus (Mouse) RFL410MF Recombinant Full Length Mouse Mitofusin-2(Mfn2) Protein, His-Tagged E.coli expression system His Full Length (1-757)
Rattus norvegicus (Rat) RFL15589RF Recombinant Full Length Rat Mitofusin-2(Mfn2) Protein, His-Tagged E.coli expression system His Full Length (1-757)
Zebrafish MFN2-6819Z Recombinant Zebrafish MFN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MFN2 Related Articles
  • MFN2 Related Research Area

MFN2 involved in several pathways and played different roles in them. We selected most pathways MFN2 participated on our site, such as Factors involved in megakaryocyte development and platelet production, Hemostasis, Mitophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Factors involved in megakaryocyte development and platelet productionZFPM1;DOCK2;ITPK1;KIF22;H3F3B.1;KIF15;KIFC1;KIF2B;KIF2C
HemostasisABHD12;RHOB;KIF2A;DGKG;GLG1B;C6orf25;MAFGA;HBG1;DOCK10
MitophagyTOMM7;TOMM70A;MTERFD1;TOMM20;TOMM6;TOMM40;MAP1LC3B;MFN2;TOMM20B
Pink/Parkin Mediated MitophagyLC3;TOMM7;TOMM22;TOMM70A;MAP1LC3B;TOMM40;TOMM20B;TOMM5;MFN2

MFN2 has several biochemical functions, for example, GTP binding, GTPase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFN2 itself. We selected most functions MFN2 had, and list some proteins which have the same functions with MFN2. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAB18B;RAB6A;SEPT9;SUCLG2;RAB11B;ARL13B;SEPT1;RAB1BB;RSG1
GTPase activityMXC;ARL2;ARL4C;GNA11;MXB;RAB13;MXG;EIF5;RHOG
protein bindingMYO15;ZNF346;SOX6;SMN1;SYK;TACR3;GNAQ;SOS1;SLC16A3
ubiquitin protein ligase bindingGABARAP;HSPD1;RNF40;UBE2V1;LRPPRC;SNCAIP;EGFR;UBE2J1;GPR37

MFN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MFN2.

LRRK2; VCP; TCHP; MARCH5; BAK1

Li, J; Ke, WB; et al. Tumour necrosis factor- alpha promotes liver ischaemia-reperfusion injury through the PGC-1 alpha/Mfn2 pathway. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 18:1863-1873(2014).
Pinne, M; Matsunaga, J; et al. Leptospiral Outer Membrane Protein Microarray, a Novel Approach to Identification of Host Ligand-Binding Proteins. JOURNAL OF BACTERIOLOGY 194:6074-6087(2012).
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