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MGAT4B

Official Full Name

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Overview

This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.
Synonyms

MGAT4B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B; mannosyl (alpha 1,3 ) glycoprotein beta 1,4 N acetylglucosaminyltransferase, isoenzyme B; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; GnT Ivb; Alpha 1 3 mannosyl glycoprotein beta 1 4 N acetylglucosaminyltransferase; Aminyltransferase; GlcNAc T IVb; GNT IV; GNTIV; GNTIVB; Mannosyl (alpha 1 3) glycoprotein beta 1 4 N acetylglucosaminyltransferase isozyme B; MGAT 4B; N acetylglucosaminyltransferase IVb; N glycosyl oligosaccharide glycoprotein; N glycosyl oligosaccharide glycoprotein N acetylglucosaminyltransferase IVb; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IV; UDP N acetylglucosamine alpha 1 3 D mannoside beta 1 4 N acetylglucosaminyltransferase IVb; glcNAc-T IVb; N-acetylglucosaminyltransferase IVb; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; GNT-IV; GNT-IVB;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N
6×His, GFP

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MGAT4B-4341HCL	Recombinant Human MGAT4B 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MGAT4B-6228HF	Recombinant Full Length Human MGAT4B Protein, GST-tagged	In Vitro Cell Free System	GST	563 amino acids	Inquiry
Human	MGAT4B-4365H	Recombinant Human MGAT4B Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MGAT4B-06H	Recombinant Human MGAT4B Protein (AA 41-548), N-6×His/GFP tagged	HEK293	N-6×His, GFP	AA 41-548	Inquiry
Mouse	MGAT4B-9811M	Recombinant Mouse MGAT4B Protein	Mammalian Cell	His		Inquiry
Mouse	MGAT4B-5535M-B	Recombinant Mouse MGAT4B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MGAT4B-5535M	Recombinant Mouse MGAT4B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MGAT4B-2761R	Recombinant Rhesus monkey MGAT4B Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MGAT4B-2582R	Recombinant Rhesus Macaque MGAT4B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MGAT4B-2582R-B	Recombinant Rhesus Macaque MGAT4B Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MGAT4B-399Z	Recombinant Zebrafish MGAT4B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MGAT4B involved in several pathways and played different roles in them. We selected most pathways MGAT4B participated on our site, such as Asparagine N-linked glycosylation, Metabolic pathways, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asparagine N-linked glycosylation	AREG;SEC24A;MIA3;SERPINA1L;CNIH;CNIH3;DERL2;TMED2;MGAT4B
Metabolic pathways	SEPHS2;POLR2I;ADPGK;NNT;PNMT;AKR1D1;FAH;CEL.1;MTMR1A
Metabolism of proteins	APEH;THSD1;ADAMTS3;OTOP2;PFDN5;SEC61B;CCT7;SEC22C;PROZ
N-Glycan antennae elongation	ST8SIA2;ST8SIA3;MGAT4B;MGAT4A
N-Glycan biosynthesis	ALG6;ALG10;FUT8;ALG10B;MAN1B1;MAN2A2;ALG9;FUT8A;ST6GAL2
N-glycan antennae elongation in the medial/trans-Golgi	MGAT4B;ST8SIA2;ST8SIA3;MGAT4A
Post-translational protein modification	SENP1;SAE1;SSPO;LMAN2;OTOP2;MAN1A2;PROZ;C8orf84;NAPG
Transport to the Golgi and subsequent modification	SEC16B;TRAPPC10;PPP6R3;YKT6;TRAPPC6B;NAPG;TRAPPC6A;CNIH;TRAPPC1

MGAT4B has several biochemical functions, for example, alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT4B itself. We selected most functions MGAT4B had, and list some proteins which have the same functions with MGAT4B. You can find most of the proteins on our site.

Function	Related Protein
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	4931440L10Rik;MGAT4C;MGAT4B;MGAT4A
metal ion binding	ZEB2;USP4;POLI;Car4;PTGS2;DYTN;ZNF668;DGCR8;PDLIM3A

MGAT4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT4B here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT4B.

LRSAM1; bgaB