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MGLL

  • Official Full Name

    Mgll monoglyceride lipase

  • Overview

    This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of;monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several;physiological processes including pain and nociperception through hydrolysis of the endocannabinoid;2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    MGLL; monoglyceride lipase; monoacylglycerol lipase; Mgl; Magl; AA589436;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • N/A
  • N
  • No tag
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MGLL-17H Active Recombinant Human MGLL protein, His-tagged (Bioactivity Validated) E.coli His
Human MGLL-2943H Recombinant Human Monoglyceride Lipase, T7-tagged E.coli T7
Human MGLL-2863H Recombinant Human Monoglyceride Lipase, His-tagged E.coli His
Human MGLL-4331HCL Recombinant Human MGLL 293 Cell Lysate HEK293 N/A
Human MGLL-4330HCL Recombinant Human MGLL 293 Cell Lysate HEK293 N/A
Human MGLL-103H Recombinant Human MGLL Protein, His-tagged E. coli His 2-313
Human MGLL-5303H Recombinant Human MGLL Protein, GST-tagged Wheat Germ GST
Human MGLL-3221H Recombinant Human MGLL protein, GST-tagged E.coli GST 1-303aa
Human MGLL-39H Recombinant Human MGLL Protein, His-tagged E.coli His 2-313
Human MGLL18930H Recombinant Human MGLL (1-303) (K36A L169S L176S) Protein
Human MGLL-2006H Recombinant Human MGLL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MGLL-6515HF Recombinant Full Length Human MGLL Protein, GST-tagged In Vitro Cell Free System GST 313 amino acids
Human MGLL-0324H Recombinant Human MGLL Protein (P2-P303), His tagged E.coli His P2-P303
Human MGLL-1407H-B Recombinant Human MGLL Protein Pre-coupled Magnetic Beads HEK293
Human MGLL-3983H Recombinant Human MGLL Protein (Met1-Pro303), N-His tagged E.coli N-His Met1-Pro303
Human MGLL-730HFL Recombinant Full Length Human MGLL Protein, C-Flag-tagged Mammalian cells Flag
Human MGLL-1407H Recombinant Human MGLL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MGLL-0323H Recombinant Human MGLL Protein (P2-P303), Tag Free E.coli No tag P2-P303
Mouse MGLL-9816M Recombinant Mouse MGLL Protein Mammalian Cell His
Mouse MGLL-5540M-B Recombinant Mouse MGLL Protein Pre-coupled Magnetic Beads HEK293
Mouse MGLL-5540M Recombinant Mouse MGLL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MGLL-2105M Recombinant Mouse MGLL Protein (1-303 aa), His-tagged Yeast His 1-303 aa
Mouse MGLL-2215M Recombinant Mouse MGLL Protein (1-303 aa), His-SUMO-tagged E.coli His/SUMO 1-303 aa
Mouse Mgll-4060M Recombinant Mouse Mgll Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Mgll-206R Recombinant Rat Mgll, His-tagged Yeast His AA 1-303
Rat MGLL-3673R Recombinant Rat MGLL Protein Mammalian Cell His
Rat MGLL-3329R Recombinant Rat MGLL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MGLL-3329R-B Recombinant Rat MGLL Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MGLL-10628Z Recombinant Zebrafish MGLL Mammalian Cell His
Chicken MGLL-4737C Recombinant Chicken MGLL Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MGLL Related Articles
  • MGLL Related Research Area

MGLL involved in several pathways and played different roles in them. We selected most pathways MGLL participated on our site, such as Acyl chain remodeling of DAG and TAG, Arachidonate production from DAG, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGLL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Acyl chain remodeling of DAG and TAGAWAT2;DGAT1B;MGLL;AWAT1
Arachidonate production from DAGMGLL;ABHD6B;ABHD12
Effects of PIP2 hydrolysisABHD12;TRPC7;DGKB;TRPC6A;DGKA;DGKQ;DGKG;MGLL;TRPC3
G alpha (q) signalling eventsGPR132B;EDNRAB;RGS21;TRIO;TAC3;ABHD12;CHRM1;APPB;DGKQ
GPCR downstream signalingCRHR1;UTS2D;TRIO;CALCB;ADORA3;CHRM4;NMS;ARHGEF16;TAS2R16
Gastrin-CREB signalling pathway via PKC and MAPKEDN2;DGKA;ABHD12;NMB;TRPC6A;TAC1;QRFPR;GCGB;OPN4
Glycerolipid metabolismALDH9A1A.1;DGKG;MOGAT3A;DGAT2;LPIN3;AKR1B10;DAK;LPIN2;AKR1B7
Glycerophospholipid biosynthesisCDIPT;PITPNB;CPNE6;PLB1;CEPT1;CPNE7;PTPMT1;PNPLA8;PEMT

MGLL has several biochemical functions, for example, acylglycerol lipase activity, lysophospholipase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGLL itself. We selected most functions MGLL had, and list some proteins which have the same functions with MGLL. You can find most of the proteins on our site.

Function Related Protein
acylglycerol lipase activityPNLIPRP2;ABHD12;MGLL;ABHD6;FAAH
lysophospholipase activityPNPLA7;MGLL;Cel;PLB1;LYPLAL1;LGALS13;PLA2G4B;PNPLA6;ASPG
protein homodimerization activityINHBB;GZMA;ADRA2C;HPS4;VEGFA;CRTAM;OSTA;ABCD1;CLIC6

MGLL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGLL here. Most of them are supplied by our site. Hope this information will be useful for your research of MGLL.

CHGB; mdtI; q5ngv3_fratt

Njie, YF; He, F; et al. Aqueous humor outflow effects of 2-arachidonylglycerol. EXPERIMENTAL EYE RESEARCH 87:106-114(2008).
Cotes, K; Dhouib, R; et al. Characterization of an exported monoglyceride lipase from Mycobacterium tuberculosis possibly involved in the metabolism of host cell membrane lipids. BIOCHEMICAL JOURNAL 408:417-427(2007).
Hamosh, M; et al. Protective function of proteins and lipids in human milk. BIOLOGY OF THE NEONATE 74:163-176(1998).
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