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MGP

  • Official Full Name

    Matrix Gla Protein

  • Overview

    The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    matrix Gla protein; Cell growth-inhibiting gene 36 protein; MGLAP; NTI; OTTHUMP00000239335; MGP; GIG36; OTTHUMP00000239337;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|GST
  • His|S
  • His|T7
  • N/A
  • N
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MGP-164H Recombinant Human MGP protein, T7/His-tagged E.coli T7/His
Human MGP-3641H Recombinant Human MGP, His-tagged Human His
Human MGP-4329HCL Recombinant Human MGP 293 Cell Lysate HEK293 N/A
Human MGP-3222H Recombinant Human MGP protein, His-tagged E.coli His 20-96aa
Human MGP-3223H Recombinant Human MGP protein, His&Myc-tagged E.coli His&Myc 20-96aa
Human MGP-5306H Recombinant Human MGP Protein, GST-tagged Wheat Germ GST
Human MGP-4547H Recombinant Human MGP Protein (Tyr20-Lys103), N-His tagged E.coli N-His Tyr20-Lys103
Human MGP-2596H Recombinant Human MGP protein, His-tagged E.coli His 1-103 aa
Human MGP-6519HF Recombinant Full Length Human MGP Protein, GST-tagged In Vitro Cell Free System GST 103 amino acids
Mouse MGP-9818M Recombinant Mouse MGP Protein Mammalian Cell His
Mouse Mgp-7011M Recombinant Mouse Mgp protein, His & S-tagged E.coli His/S Tyr20~Tyr104 (Accession # P19788)
Mouse MGP-95M Recombinant Mouse Mgp Protein, His-tagged E.coli His Tyr20~Tyr104
Mouse MGP-5542M Recombinant Mouse MGP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MGP-5542M-B Recombinant Mouse MGP Protein Pre-coupled Magnetic Beads HEK293
Rat MGP-3675R Recombinant Rat MGP Protein Mammalian Cell His
Rat Mgp-7013R Recombinant Rat Mgp protein, His-tagged E.coli His Tyr20~Lys103
Rat Mgp-7014R Recombinant Rat Mgp protein, His & T7-tagged E.coli His/T7 Met1~Lys103 (Accession # P08494)
Rat MGP-3331R-B Recombinant Rat MGP Protein Pre-coupled Magnetic Beads HEK293
Rat MGP-3331R Recombinant Rat MGP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit MGP-7015R Recombinant Rabbit MGP protein, His & GST-tagged E.coli His/GST Tyr20~Glu103 (Accession # P47841)
Cattle MGP-7010C Recombinant Cattle MGP protein, His & GST-tagged E.coli His/GST Tyr20~Lys103 (Accession # P07507)
Rhesus Macaque MGP-2765R Recombinant Rhesus monkey MGP Protein, His-tagged Mammalian Cell His
Rhesus Macaque MGP-2586R Recombinant Rhesus Macaque MGP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MGP-2586R-B Recombinant Rhesus Macaque MGP Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MGP-11672Z Recombinant Zebrafish MGP Mammalian Cell His
Pig MGP-7012P Recombinant Pig MGP protein, His & GST-tagged E.coli His/GST His23~Lys103 (Accession # Q8MJ39)
Chicken MGP-6601C Recombinant Chicken MGP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MGP Related Articles

MGP involved in several pathways and played different roles in them. We selected most pathways MGP participated on our site, such as Endochondral Ossification, Validated transcriptional targets of AP1 family members Fra1 and Fra2, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Endochondral OssificationCOL10A1A;PTHLHA;FRZB;COL10A1;ADAMTS1;IFT88;DDR2;ADAMTS4;MGP
Validated transcriptional targets of AP1 family members Fra1 and Fra2CXorf15;MGP;USF2;IVL;BGLAP

MGP has several biochemical functions, for example, calcium ion binding, extracellular matrix structural constituent, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGP itself. We selected most functions MGP had, and list some proteins which have the same functions with MGP. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPKD2L1;CDH9;ALOX8;PVALB2;MYL4;SCIN;ANXA11A;ANXA1C;SMOC1
extracellular matrix structural constituentTFPI2;KAL1;FBN1;LAMC1;COL5A1;COL27A1A;IMPG1;MATN1;COL11A1A
protein bindingPACSIN1;SMG9;RANBP3;NMU;RAP1A;DDX23;CST3;SLC41A3;SUV420H2
structural constituent of boneBGLAP2;BGLAP-RS1;MGP;BGLAP

MGP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGP here. Most of them are supplied by our site. Hope this information will be useful for your research of MGP.

p27958-pro_0000037576

Viegas, CSB; Rafael, MS; et al. Gla-Rich Protein Acts as a Calcification Inhibitor in the Human Cardiovascular System. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35:399-408(2015).
Xiao, LP; Esliger, A; et al. Nuclear Fibroblast Growth Factor 2 (FGF2) Isoforms Inhibit Bone Marrow Stromal Cell Mineralization Through FGF23/FGFR/MAPK In Vitro. JOURNAL OF BONE AND MINERAL RESEARCH 28:35-45(2013).
  • Q&As
  • Reviews

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Customer Reviews (3)

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Reviews
05/10/2022

    Considering its stability, experimental results remain reliable and consistent, leaving no room for doubt.

    06/17/2017

      Users can rely on comprehensive technical support provided by the manufacturer, addressing inquiries and concerns.

      03/15/2016

        The handling process for this reagent is simple, eliminating the need for intricate separation and purification steps.

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