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MGST1

Official Full Name

microsomal glutathione S-transferase 1
Overview

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Four transcript variants of this gene encode one protein isoform.
Synonyms

MGST1; microsomal glutathione S-transferase 1; GST12; MGST I; Glutathione S transferase 12; MGST 1; MGST; MGST1_HUMAN; Microsomal GST 1; Microsomal GST-1; Microsomal GST-I; glutathione S-transferase 12; MGST-I;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Bos taurus (Bovine)
Chicken
Cynomolgus Monkey
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)
Sus scrofa (Pig)

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|GST
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MGST1-220H	Recombinant Human MGST1	Mammalian Cell	His		Inquiry
Human	MGST1-30203TH	Recombinant Human MGST1	Wheat Germ	N/A	155 amino acids	Inquiry
Human	MGST1-1110HCL	Recombinant Human MGST1 cell lysate		N/A		Inquiry
Human	MGST1-2439H	Recombinant Human MGST1 Protein, His-tagged	E.coli	N-His	Thr34-Pro128	Inquiry
Human	MGST1-5309H	Recombinant Human MGST1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MGST1-6522HF	Recombinant Full Length Human MGST1 Protein, GST-tagged	In Vitro Cell Free System	GST	155 amino acids	Inquiry
Human	MGST1-305HF	Recombinant Full Length Human MGST1 Protein	In Vitro Cell Free System		155 amino acids	Inquiry
Human	MGST1-3473H	Recombinant Human MGST1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	MGST1-3473H-B	Recombinant Human MGST1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Mgst1-2653M	Recombinant Mouse Mgst1 protein, His & GST-tagged	E.coli	His/GST	Met8~Leu155 (Accession # Q91VS7)	Inquiry
Rat	Mgst1-1777R	Recombinant Rat Mgst1 Protein, His-tagged	E.coli	N-His	Gln6-Leu155	Inquiry
Bos taurus (Bovine)	RFL7688BF	Recombinant Full Length Bovine Microsomal Glutathione S-Transferase 1(Mgst1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-155)	Inquiry
Cynomolgus Monkey	MGST1-692C	Recombinant Cynomolgus MGST1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Cynomolgus Monkey	MGST1-438C	Recombinant Cynomolgus Monkey MGST1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Cynomolgus Monkey	MGST1-438C-B	Recombinant Cynomolgus Monkey MGST1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL30785HF	Recombinant Full Length Human Microsomal Glutathione S-Transferase 1(Mgst1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-155)	Inquiry
Mus musculus (Mouse)	RFL27854MF	Recombinant Full Length Mouse Microsomal Glutathione S-Transferase 1(Mgst1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-155)	Inquiry
Rattus norvegicus (Rat)	RFL31942RF	Recombinant Full Length Rat Microsomal Glutathione S-Transferase 1(Mgst1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-155)	Inquiry
Sus scrofa (Pig)	RFL1101SF	Recombinant Full Length Pig Microsomal Glutathione S-Transferase 1(Mgst1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (2-155)	Inquiry
Chicken	MGST1-3869C	Recombinant Chicken MGST1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MGST1 Related Articles

MGST1 involved in several pathways and played different roles in them. We selected most pathways MGST1 participated on our site, such as Glutathione metabolism, Metabolism of xenobiotics by cytochrome P, Drug metabolism - cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glutathione metabolism	GPX2;IDH1;GGCTA;GGT1;RRM2B;RRM1;GPX1;RRM2;GSTT2B
Metabolism of xenobiotics by cytochrome P	UGT1AB;UGT2B15;MGST1.2;UGT1A6B;UGT1A6;MGST3;MGST1.1;UGT2B7;GSTM6
Drug metabolism - cytochrome P	GSTM7;UGT1AB;GSTA1;GSTM6;UGT1A6B;UGT2B7;FMO5;GSTT2;UGT1A6
Chemical carcinogenesis	EPHX1;Nat3;ARNT;ADH4;CYP2C9;GSTT2B;UGT1A6B;ALDH3B1;GSTK1

MGST1 has several biochemical functions, for example, glutathione binding, glutathione peroxidase activity, glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGST1 itself. We selected most functions MGST1 had, and list some proteins which have the same functions with MGST1. You can find most of the proteins on our site.

Function	Related Protein
glutathione binding	PTGES2;GSTM2;GSTP2;PTGES;GSS;GSTM4;GSTM7;GPX1;LANCL1
glutathione peroxidase activity	GPX1B;GPX6;GPX2;GPX4;MGST1;MGST2;GSTZ1;GSTK1;GSTT1
glutathione transferase activity	GSTK1;GSTM1;GSTM6;GSTA2;GSTM;GSTA4;GSTA5;GSTT1B;GDAP1L1
protein binding	EDA2R;BMP1;TFCP2;CPNE7;FAM9B;PALM;KAT7;EEF1A2;ALKBH6
protein homodimerization activity	LRP6;ADD1;FGFR1OP2;GRIK2;APOE;LGALS6;CLN6;PLDN;HARS2

MGST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGST1.

NELFB; ERBB2

Weng, ZQ; Greenhaw, J; et al. Mechanisms for epigallocatechin gallate induced inhibition of drug metabolizing enzymes in rat liver microsomes. TOXICOLOGY LETTERS 214:328-338(2012).

Boczek, T; Kozaczuk, A; et al. Adaptation of microsomal glutathione transferase 1 in PC12 cells with modified PMCA isoforms composition. INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS 47:265-271(2010).