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MKKS

Official Full Name

McKusick-Kaufman syndrome
Overview

This gene encodes a protein with sequence similarity to the chaperonin family. The encoded protein may have a role in protein processing in limb, cardiac and reproductive system development. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6 and McKusick-Kaufman syndrome. Two transcript variants encoding the same protein have been identified for this gene.
Synonyms

MKKS; McKusick-Kaufman syndrome; BBS6; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Bardet Biedl syndrome 6 protein; HMCS; KMS; McKusick Kaufman syndrome; McKusick Kaufman/Bardet Biedl syndromes putative chaperonin; MKS; bardet-Biedl syndrome 6 protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rhesus Macaque
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MKKS-726H	Recombinant Human MKKS	Mammalian Cell	His		Inquiry
Human	MKKS-1114HCL	Recombinant Human MKKS cell lysate		N/A		Inquiry
Human	MKKS-3478H	Recombinant Human MKKS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	MKKS-5362H	Recombinant Human MKKS Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MKKS-6276HF	Recombinant Full Length Human MKKS Protein, GST-tagged	In Vitro Cell Free System	GST	570 amino acids	Inquiry
Human	MKKS-3478H-B	Recombinant Human MKKS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	MKKS-2777R	Recombinant Rhesus monkey MKKS Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MKKS-2598R	Recombinant Rhesus Macaque MKKS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MKKS-2598R-B	Recombinant Rhesus Macaque MKKS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MKKS-10512Z	Recombinant Zebrafish MKKS	Mammalian Cell	His		Inquiry
Chicken	MKKS-4284C	Recombinant Chicken MKKS	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MKKS Related Articles

MKKS involved in several pathways and played different roles in them. We selected most pathways MKKS participated on our site, such as Assembly of the primary cilium, BBSome-mediated cargo-targeting to cilium, Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKKS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	TCTEX1D1;WDR34;CYS1;DYF-1;KIF3C;ACTR1A;KIF3A;CCP110;EXOC1
BBSome-mediated cargo-targeting to cilium	BBS5;BBS2;BBS7;SSTR3;CCT3;BBS9;BBS12;RAB3IP;MKKS
Cargo trafficking to the periciliary membrane	BBS5;SSTR3;BBS12;PROL1;MKKS;BBS7;BBS1;RHOL;ARF4
Organelle biogenesis and maintenance	TUFM;IFT80;MTFMT;UNC119B;CCDC123;CLUAP1;MTRF1L;MRPL49;IFT27

MKKS has several biochemical functions, for example, ATP binding, RNA polymerase II repressing transcription factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKKS itself. We selected most functions MKKS had, and list some proteins which have the same functions with MKKS. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	TBCK;MLH1;YARS2;MYH1E;CUL9;UHMK1;WNK2;CDK2;PSMC6
RNA polymerase II repressing transcription factor binding	HDAC2;TCERG1;GTF2A2;GATA6;RBPJ;BBS2;TCF7L2;CHD4;BBS5
protein binding	TSSK4;SALL1;BRE;IRF2BP1;FCN3;MMP9;MYH8;SAE1;CSRP2BP
unfolded protein binding	HSP104;TOR1A;HSP26;CHAF1B;CRYAB;CALR3;CCT2;ERO1LB;CDC37

MKKS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKKS here. Most of them are supplied by our site. Hope this information will be useful for your research of MKKS.

BBS7; BBS10; BBS12

Rao, KP; Vani, G; et al. Arsenic stress activates MAP kinase in rice roots and leaves. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 506:73-82(2011).

Zhao, Y; Herdegen, T; et al. Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria. MOLECULAR AND CELLULAR NEUROSCIENCE 41:186-195(2009).