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MKL1

  • Official Full Name

    megakaryoblastic leukemia (translocation) 1

  • Overview

    MKL/megakaryoblastic leukemia 1 is a protein that in humans is encoded by the MKL1 gene.
  • Synonyms

    MKL1; megakaryoblastic leukemia (translocation) 1; MKL/myocardin-like protein 1; basic; SAP and coiled coil domain; BSAC; KIAA1438; MAL; megakaryocytic acute leukemia; MRTF A; myocardin related transcription factor A; basic, SAP and coiled-coil domain; me;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MKL1-893H Recombinant Human MKL1, GST-tagged E.coli GST 392-741aa
Human MKL1-1153H Recombinant Human MKL1 protein, His-KSI-tagged E.coli His-KSI 400-500aa
Mouse MKL1-9861M Recombinant Mouse MKL1 Protein Mammalian Cell His
Mouse MKL1-5572M-B Recombinant Mouse MKL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse MKL1-5572M Recombinant Mouse MKL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MKL1 involved in several pathways and played different roles in them. We selected most pathways MKL1 participated on our site, such as RHO GTPase Effectors, RHO GTPases Activate Formins, RhoA signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MKL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RHO GTPase EffectorsNDEL1B;ABI1B;RTKN;NSL1;PRC1B;PMF1;KIF14;ZW10;SKA2
RHO GTPases Activate ForminsEVL;RANGAP1B;SPC25;SGOL2;RCC2;MKL1B;RHOAE;MKL1;FMNL1
RhoA signaling pathwayMKL1;ACTA1;DIAPH1;CYR61
Signal TransductionFAM13B;OPN4B;SOX13;ARHGAP40;MAPK6;NPHP4;LRIG1;TAGAP1;TAX1BP1B
Signaling by Rho GTPasesLIN7B;ARHGAP20;RHOT1B;ARHGAP6;ARHGEF17;RHPN1;RHOF;KIF14;RTKN

MKL1 has several biochemical functions, for example, RNA polymerase II transcription coactivator activity, actin binding, actin monomer binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MKL1 itself. We selected most functions MKL1 had, and list some proteins which have the same functions with MKL1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription coactivator activityCITED1;MED12;MKL1;CITED4;POU1F1;MKL1B;POU3F1;PSIP1;CREBBP
actin bindingMYH7B;MYO15;PARVB;TNNI3;PDLIM5;CYFIP1;ESPN;FHOD3;FMN2
actin monomer bindingMYL3;LIMA1;PFN4;TMSB4Y;TMSB15B;TWF1;MYL2;KLHL8;LMOD3
leucine zipper domain bindingCRX;DDIT3;MKL1;PAWR;KCNA3;DAPK3;ERC1;PMF1;NRL
protein bindingSLA;DNAJC5B;NSL1;ARMCX5-GPRASP2;ZNF124;TBC1D1;ZNF830;GZMM;ATP5B
transcription coactivator activityAnkar;SMARCD1;PQBP1;JUN;TAF6L;USP22;TBPL1;TAF5L;DYRK1B
transcription factor activity, sequence-specific DNA bindingSIX1;NR1D4B;ZFP639;FUBP1;ZNF19;GRHL3;RBPJB;TLX2;ZNF157
transcription regulatory region sequence-specific DNA bindingBACH1B;EPAS1B;EGR1;NKX3;MKL1;NR5A2;SOX11;SFPQ;PITX2

MKL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MKL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MKL1.

SRF; MKL2; frwC; MYC

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