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MLC1

Official Full Name

megalencephalic leukoencephalopathy with subcortical cysts 1
Overview

The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

MLC1; megalencephalic leukoencephalopathy with subcortical cysts 1; membrane protein MLC1; KIAA0027; LVM; MLC; VL;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MLC1-3927H	Active Recombinant Human MLC1 Full Length Transmembrane protein(Nanodisc)	HEK293	N/A	Inquiry
Mouse	MLC1-9872M	Recombinant Mouse MLC1 Protein	Mammalian Cell	His	Inquiry
Mouse	MLC1-5577M	Recombinant Mouse MLC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	MLC1-5577M-B	Recombinant Mouse MLC1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	MLC1-2779R	Recombinant Rhesus monkey MLC1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	MLC1-2600R	Recombinant Rhesus Macaque MLC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	MLC1-2600R-B	Recombinant Rhesus Macaque MLC1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Zebrafish	MLC1-5980Z	Recombinant Zebrafish MLC1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MLC1 Related Articles

MLC1 involved in several pathways and played different roles in them. We selected most pathways MLC1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MLC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MLC1 has several biochemical functions, for example, NOT ion channel activity, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLC1 itself. We selected most functions MLC1 had, and list some proteins which have the same functions with MLC1. You can find most of the proteins on our site.

Function	Related Protein
NOT ion channel activity	MLC1;CCDC109B
protein binding	PIK3CG;PPM1K;DIS3;PEX14;HEYL;HIPK1;MICAL1;GOLSYN;ABL1
protein complex binding	TULP2;KHDRBS1;PPIB;CPS1;RRAS;CDK2;SIX2;BAG3;HADHA
protein transporter activity	AP1G1;IPO5;DSCR3;ARFGAP3;SEC62;RAMP3;AP1S1;KPNA2;AP4S1

MLC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MLC1.

Masaki, K; Suzuki, SO; et al. Extensive loss of connexins in Bal's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction. ACTA NEUROPATHOLOGICA 123:887-900(2012).

Gundlach, CW; Caivano, A; et al. Synthesis and Evaluation of an Anti-MLC1 x Anti-CD90 Bispecific Antibody for Targeting and Retaining Bone-Marrow-Derived Multipotent Stromal Cells in Infarcted Myocardium. BIOCONJUGATE CHEMISTRY 22:1706-1714(2011).