MLKL
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Official Full Name
mixed lineage kinase domain-like
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Synonyms
MLKL; mixed lineage kinase domain-like; mixed lineage kinase domain-like protein; FLJ34389;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Wheat Germ
- Yeast
- GST
- His
- His|SUMO
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
MLKL involved in several pathways and played different roles in them. We selected most pathways MLKL participated on our site, such as DNA damage response (only ATM dependent), Programmed Cell Death, RIPK1-mediated regulated necrosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MLKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response (only ATM dependent) | BIK;DVL2;DVL1;DVL3;MLKL |
| Programmed Cell Death | RIPK3;DBNL;DSP;PKP1;CASP6L2;DSG2;STK24A;DIABLOA;Gzmg |
| RIPK1-mediated regulated necrosis | |
| Regulated Necrosis | |
| TNF signaling pathway | MAP3K14;BAG4;IL1B;CCL2;MAPK8;BIRC2;CXCL5;SOCS3;CXCL2 |
MLKL has several biochemical functions, for example, ATP binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MLKL itself. We selected most functions MLKL had, and list some proteins which have the same functions with MLKL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | STK31;ABCG5;CIT;ATP2B3A;EIF4A2;FGFR1A;ADRBK1;RPS6KA3A;DGKB |
| protein binding | GPR85;HDAC6;MYOM1;NCK2;FAM82A2;PNKD;EXOSC2;RIMS1;MYH10 |
| protein complex binding | PPIB;ITGB1BP1;GNB1;KRAS;BRK1;SHANK1;ING2;DRD1A;RANBP2 |
| NOT protein kinase activity | MLKL;STRADB;PXK;STRADA;TRIB1;HSPB8;TRIB2 |
| protein kinase binding | GDF3;CCNT2B;BAG5;RICTOR;PARK2;PRKACA;NEK9;SFN;CNTLN |
| protein serine/threonine kinase activity | CLK4;TBK1;CSNK2A2;CDK5;ALPK1;TTN;MELK;ILK;DAPK2 |
MLKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MLKL here. Most of them are supplied by our site. Hope this information will be useful for your research of MLKL.
RIPK3; necrosulfonamide; PITPNA; CDK1; NDUFB7; THOC3; RAD18; ANAPC11
- Q&As
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