mogs
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  • Official Full Name
  • mannosyl-oligosaccharide glucosidase
  • Background
  • This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • MOGS; mannosyl-oligosaccharide glucosidase; GCS1; glucosidase I; processing A glucosidase I; processing A-glucosidase I; CDG2B
Cat.#:MOGS-7916HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MOGS protein, His & T7-tagged
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Cat.#:Mogs-7917MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mogs protein, His & T7-tagged
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Cat.#:MOGS-9954MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MOGS Protein
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Cat.#:MOGS-5046ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MOGS
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Involved Pathway

MOGS involved in several pathways and played different roles in them. We selected most pathways MOGS participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOGS were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
N-Glycan biosynthesis
GANAB; ALG12; MGAT5; MAN1A2; MGAT2; ALG10; MAN1A; DAD1; MGAT4A; MGAT1
Metabolic pathways
GAD1B; PNAT10; HSD3B6; ALOX15B; ENPP3; GLUD1A; ADH1B; HK2; GATC; NDUFA4L2
Protein processing in endoplasmic reticulum
STT3A; BAG1; SEC24C; CCDC102A; RBX1; TRAF2; HERPUD1; HYOU1; DNAJB12A; LMAN1L

Protein Function

MOGS has several biochemical functions, for example, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds. Some of the functions are cooperated with other proteins, some of the functions could acted by MOGS itself. We selected most functions MOGS had, and list some proteins which have the same functions with MOGS. You can find most of the proteins on our site.
Function
Related Protein
Function catalytic activity
Related Protein TPI1A; GMPR2; LYZ1; SPTLC2B; MOXD2; GNSB; GOT2B; ACSL3B; RTCD1; PBLD1
Function hydrolase activity
Related Protein YTHDC2; PPM1BB; GDPD4; GGT7; ATP8B1; TIGARA; RNASEL2; ABHD8; C9orf156; RTEL1
Function hydrolase activity, acting on glycosyl bonds
Related Protein HYAL6; MOGS; SMPDL3A; GALCA; SPACA5; MAN1A; MACROD1; SMPD1; LYZ1; MUTYH
Function mannosyl-oligosaccharide glucosidase activity
Related Protein MOGS

Interacting Protein

MOGS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOGS here. Most of them are supplied by our site. Hope this information will be useful for your research of MOGS.
Hmga2; Ywhae; Ywhab; Hsd3b7

MOGS Related Articles

Kozela, E; Juknat, A; et al. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. JOURNAL OF NEUROINFLAMMATION 12:-(2015).
Probstel, AK; Rudolf, G; et al. Anti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype. JOURNAL OF NEUROINFLAMMATION 12:-(2015).