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MOV10

  • Official Full Name

    Mov10, Moloney leukemia virus 10, homolog (mouse)

  • Overview

    MOV10 may be an helicase with an important function in development and/or control of cell proliferation. RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs). They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affect stability and translation of partial complementary mRNAs. Argonaute (Ago) proteins are at the heart of silencing effector complexes and bind the single-stranded siRNA and miRNA. Ago1- and Ago2-containing complexes have been purified from human cells, resulting in the discovery of novel factors such as the putative RNA helicase MOV10, and the RNA recognition motif (RRM)-containing protein TNRC6B/KIAA1093. The new proteins localize, similar to Ago proteins, to mRNA-degrading cytoplasmic P bodies, and they are functionally required to mediate miRNA-guided mRNA cleavage.
  • Synonyms

    MOV10; Mov10, Moloney leukemia virus 10, homolog (mouse); gb110; fSAP113; putative helicase MOV-10; moloney leukemia virus 10 protein; functional spliceosome-associated protein 113;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MOV10-946H Recombinant Human MOV10, GST-tagged E.coli GST 869-1004aa
Human MOV10-4242HCL Recombinant Human MOV10 293 Cell Lysate HEK293 N/A
Human MOV10-378HFL Active Recombinant Full Length Human MOV10 Protein, C-Flag-tagged Mammalian cells Flag
Human MOV10-1865H Recombinant Human MOV10 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MOV10-1424H-B Recombinant Human MOV10 Protein Pre-coupled Magnetic Beads HEK293
Human MOV10-1424H Recombinant Human MOV10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mov10-4121M Recombinant Mouse Mov10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque MOV10-2809R Recombinant Rhesus monkey MOV10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque MOV10-2629R-B Recombinant Rhesus Macaque MOV10 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MOV10-2629R Recombinant Rhesus Macaque MOV10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken MOV10-2067C Recombinant Chicken MOV10 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MOV10 Related Articles

MOV10 involved in several pathways and played different roles in them. We selected most pathways MOV10 participated on our site, such as Adaptive Immune System, Beta-catenin independent WNT signaling, Ca2+ pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MOV10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemB2ML;UBE2U;KIF2C;KLRF1;KLRG1;KLRB1F;KLRB1A;CD96;AP2M1
Beta-catenin independent WNT signalingDVL2;AP2S1;RYK;PRICKLE1B;AGO2;CLTB;AP2M1;PRICKLE1;AGO3
Ca2+ pathwayAGO1;AGO3;AGO2;MOV10;GNB5
Cellular SenescenceHIST3H2BB;HMGA1B;CDK6;CBX8B;TINF2;CDKN2C;H3F3B.1;SUZ12;RBB4L
Cellular responses to stressCDKN2A;AMBRA1;KIAA1967;PHC2;LAMTOR1;AMBRA1A;MINK1;TERF1;CBX8B
DAP12 interactionsTREM1;CSF2RA;SIGLEC15;DUSP5;SIGLEC14;KLB;NRG4;PTPRA;IL17RD
DAP12 signalingPEBP1;THEM4;PAQR3B;DUSP4;SPTA1;SPTB;PEA15;NRG2A;FRS3
Downstream signal transductionFGF18B;MOV10;FRS2B;SPNA1;DUSP9;SPTBN2;AGO1;MARK3;IL17RD

MOV10 has several biochemical functions, for example, ATP binding, helicase activity, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MOV10 itself. We selected most functions MOV10 had, and list some proteins which have the same functions with MOV10. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSTRC;HSPA6;ERCC6L;LATS1;DDX21;NOL9;ACSF2;TTLL2;PSMC5
helicase activityGTF2F2A;PIF1;IFIH1;PL10;SHPRH;MOV10;MOV10B.1;RTEL1;ACTG2
poly(A) RNA bindingMTHFSD;DDX39B;RPL12;SYF2;DIEXF;PIN4;CLTC;UTP18;C9orf114
protein bindingIGFN1;ABHD1;NAB2;PRKCA;GLRB;KIAA1737;VPS54;APPL2;MRPL11

MOV10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MOV10 here. Most of them are supplied by our site. Hope this information will be useful for your research of MOV10.

YBX1; EIF2AK2; ATG12; PUF60; NS1; CBX4; AIM2; IFIT3; NS; GABARAP; CBX6; NS; US11; IFIT1; Rc3h2; Zfp36; MNDA; HNRNPH2

Nakano, M; Kakiuchi, Y; et al. MOV10 as a novel telomerase-associated protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 388:328-332(2009).
Wulczyn, FG; Smirnova, L; et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB JOURNAL 21:415-426(2007).
  • Q&As
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