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MRE11A

Official Full Name

MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Overview

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3 to 5 exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3 to 5 exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms

MRE11A; MRE11 meiotic recombination 11 homolog A (S. cerevisiae); ATLD; HNGS1; MRE11; MRE11B; double-strand break repair protein MRE11A; AT-like disease; MRE11 homolog 1; MRE11 homolog A; endo/exonuclease Mre11; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; DNA recombination and repair protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MRE11A-28636TH	Recombinant Human MRE11A	Wheat Germ	N/A	206 amino acids	Inquiry
Human	MRE11A-741H	Recombinant Human MRE11A Protein, His-tagged	E.coli	His		Inquiry
Human	MRE11A-4211HCL	Recombinant Human MRE11A 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MRE11A-5537H	Recombinant Human MRE11A Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MRE11A-2895H	Recombinant Human MRE11A protein, His-tagged	E.coli	His	170-400 aa	$319 / 25ug
Human	MRE11A-315HF	Recombinant Full Length Human MRE11A Protein	In Vitro Cell Free System		206 amino acids	Inquiry
Human	MRE11A-6354HF	Recombinant Full Length Human MRE11A Protein, GST-tagged	In Vitro Cell Free System	GST	206 amino acids	Inquiry
Mouse	Mre11a-4136M	Recombinant Mouse Mre11a Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Rat	MRE11A-3748R	Recombinant Rat MRE11A Protein	Mammalian Cell	His		Inquiry
Rat	MRE11A-3407R-B	Recombinant Rat MRE11A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MRE11A-3407R	Recombinant Rat MRE11A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Zebrafish	MRE11A-212Z	Recombinant Zebrafish MRE11A	Mammalian Cell	His		Inquiry
Chicken	MRE11A-6342C	Recombinant Chicken MRE11A	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MRE11A Related Research Area

MRE11A involved in several pathways and played different roles in them. We selected most pathways MRE11A participated on our site, such as Homologous recombination, Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRE11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	CDK5R2;TOP3A;RPA1;SHFM1;POLD4;RPA4;XRCC2;RPA2;EME1
Non-homologous end-joining	FEN1;POLL;LIG4;XRCC6;XRCC5;POLM;NHEJ1;MRE11A;DNTT

MRE11A has several biochemical functions, for example, 3-5 exonuclease activity, contributes_to ATP-dependent DNA helicase activity, contributes_to DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRE11A itself. We selected most functions MRE11A had, and list some proteins which have the same functions with MRE11A. You can find most of the proteins on our site.

Function	Related Protein
3-5 exonuclease activity	RAD9A;REXO2;APLF;WRN;MRE11A;POLA1;POLG;APEX1;EXD2
contributes_to ATP-dependent DNA helicase activity	MCM4;MRE11A;NBN;MCM6;RAD50;MCM7
contributes_to DNA binding	FOXH1;NFE2L2A;MLXIPL;GTF3C6;ARNTL1B;RFC3;CLOCKA;ARNTL1A;MRE11A
double-stranded DNA binding	SETMAR;TARDBP;SAFB;NEIL3;XRCC6;HMGB3;SP1;MCM10;DDX58
endodeoxyribonuclease activity	DNASE1L1;APLF;ERCC5;DNASE1;MBD4;DNASE2A;APEX1;ZRANB3;MRE11A
endonuclease activity	ANG3;SMG6;EAR5;EME1;EAR3;RNASEKA;RNASE2;ANG;ENDOU2
manganese ion binding	HMGCL;MPPE1;CDIPT;WRN;PPM1AB;PPM1BA;TDP2B;B4GALT1;PAPOLA
nuclease activity	DNASE2A;HARBI1;ZRANB3;RNASEL4;DOM3Z;TDP2B;RNASEKB;RNASEL2;REXO4
protein C-terminus binding	TOP2A;HRAS;SCLT1;ATF4;CAV3;ERCC3;TFCP2;ATP1B1;ATXN2
protein binding	SYCE1;NUP62CL;RBMX;UROD;SEPSECS;VPS37A;PTPN2;NR1D2;MYO5A
single-stranded DNA endodeoxyribonuclease activity	SETMAR;MRE11A;RBBP8;ERCC4;DCLRE1C

MRE11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRE11A here. Most of them are supplied by our site. Hope this information will be useful for your research of MRE11A.

H2AFX; FANCD2; MDC1

G2/M (DNA Damage) Checkpoints