msx1
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  • Official Full Name
  • msh homeobox 1
  • Background
  • Msh homeobox 1 (Msx1) is a Muscle Segment Homeobox (Msh) gene family member that acts as a transcriptional repressor during embryonic development, playing an important role in limb pattern formation, craniofacial development, and tooth development. Msx1 i
  • Synonyms
  • MSX1; msh homeobox 1; HOX7, msh (Drosophila) homeo box homolog 1 (formerly homeo box 7) , msh homeobox homolog 1 (Drosophila); homeobox protein MSX-1; HYD1; OFC5; homeobox 7; msh homeo box 1; homeobox protein Hox-7; msh homeobox homolog 1; msh homeobox
Cat.#:MSX1-5676HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MSX1 Protein, GST-tagged
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Cat.#:MSX1-10154MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MSX1 Protein
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Cat.#:MSX1-2881RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MSX1 Protein, His-tagged
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Cat.#:MSX1-7037CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MSX1
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Cat.#:MSX1-4105HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MSX1 293 Cell Lysate
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Involved Pathway

MSX1 involved in several pathways and played different roles in them. We selected most pathways MSX1 participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
HTLV-I infection
WNT4; LTA; PRKACA; TNFRSF13C; HLA-DRB5; EP300; CANX; IL2RB; ETS1; NFATC2

Protein Function

MSX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, p53 binding, transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSX1 itself. We selected most functions MSX1 had, and list some proteins which have the same functions with MSX1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein SUV39H1; NKX2-1; IKZF3; DMRT1; MYOG; ACTN4; GATA1A; ZNF792; NHLH2; SP5
Function p53 binding
Related Protein SIRT1; MDM2; ZNF385A; TP53; CDK5; ZFP346; BRD7; TAF3; SMARCB1; MSX1
Function transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein ARNTL2; SFPI1; SREBF1; BATF; ATF3; RBPJL; ARNTL; MSX2; HIST2H3A; BATF2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein GATA4; FOXF2; AIRE; HIF1A; OSR2; TRP53; DLX2; RXRB; ZGLP1; CREB3L4
Function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein ZBTB4; JARID2; MITF; ESX1; MSX2; FEZF2; HES6; GLIS1; FOXD3; FOXO3

Interacting Protein

MSX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSX1.
MED19; NMNAT1; ING4; PTBP3

MSX1 Related Articles

Sajan, SA; Rubenstein, JLR; et al. Identification of direct downstream targets of Dlx5 during early inner ear development. HUMAN MOLECULAR GENETICS 20:1262-1273(2011).
Houpis, CH; Tosios, KI; et al. Parathyroid hormone-related peptide (PTHrP), parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1), and MSX1 protein are expressed in central and peripheral giant cell granulomas of the jaws. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 109:415-424(2010).