mta3
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  • Official Full Name
  • metastasis associated 1 family, member 3
  • Background
  • MTA1, MTA2, and MTA3 and 594 aa (MTA3L) proteins found in both the nucleus and the cytoplasmic compartments. It was identified as an Estrogen receptor (ER) regulated component of the Mi/NuRD histone deacetylase transcriptional repressor. In response to estrogen, MTA3 directly targets Snail, the master regulator of the epithelial to mesenchymal transition (EMT). Regulation of E-cadherin expression due to MTA3 and ER mediated signaling of Snail expression may be an important pathway in human breast tumors. Loss of ER results in decreased MTA3 expression and tamoxifen reduces expression of MTA3 in endometrial cells.
  • Synonyms
  • MTA3; metastasis associated 1 family, member 3; metastasis associated gene family, member 3; metastasis-associated protein MTA3; KIAA1266; metastasis associated family, member 3
Cat.#:MTA3-5682HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTA3 Protein, GST-tagged
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Cat.#:MTA3-1072HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTA3, GST-tagged
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Cat.#:MTA3-2891RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MTA3 Protein, His-tagged
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Cat.#:MTA3-10281ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTA3
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Cat.#:MTA3-4092HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTA3 293 Cell Lysate
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Involved Pathway

MTA3 involved in several pathways and played different roles in them. We selected most pathways MTA3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
COPRS; PADI4; RBB4L; SAP30L; EP400; MSL2A; SUZ12A; SMYD2; SMARCA4; NCOA2
Chromatin organization
COPRS; MSL1A; MBD3A; KIAA1267; ASH2L; C17orf81; KAT7; TADA2A; PRMT5; ATXN7
Gene Expression
DNMT3B; POP1; ZNF664; ZNF446; SCO1; DHX9; ZNF454; ZNF729; HNRNPA0B; HNRNPL2
HDACs deacetylate histones
MBD3; MBD3B; SAP30; KDM1A; ARID4A; BRMS1; MTA2; SAP30L; GATAD2AB; HMG20B
RNA Polymerase I Promoter Clearance
GATAD2A; GATAD2AB; TAF1A; MBD3; UBTF; TAF1B; MTA1; MTA2; GATAD2B; CHD4A
RNA Polymerase I Transcription
RRN3; CD3EAP; PTRFB; GATAD2B; TAF1D; TAF1C; CHD4A; CHD4; MBD3; TAF1B
RNA Polymerase I Transcription Initiation
MBD3A; MTA1; MBD3B; GATAD2AB; MTA2; MBD3; UBTF; GATAD2B; RRN3; CHD4
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
NFIA; SNAPC4; ZNF143; CRCP; MTA3; MBD3B; GTF3A; CHD4; SNAPC2; ZFP143

Protein Function

MTA3 has several biochemical functions, for example, chromatin binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA3 itself. We selected most functions MTA3 had, and list some proteins which have the same functions with MTA3. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein TGIF1; ATOH1A; GATA6; PRDM13; GATA2; EWSR1A; CREB3; LMO2; TOX2; KLF6A
Function protein binding
Related Protein SOX6; GATSL3; PPP1R15B; OTX2; PAM16; HIST2H3C2; INVS; BMF; MDM4; BTF3
Function sequence-specific DNA binding
Related Protein DLX2B; FOXP3; FOXB1A; EVX2; NR2F2; LHX9; PRDM5; HSFX1; GTF2E1; ELF2
Function transcription factor activity, sequence-specific DNA binding
Related Protein GTF2H2; TRPS1; NR2F6; HIRA; MYOG; SPIB; MYCLB; FOSL1A; HOXA4; ZNF205
Function zinc ion binding
Related Protein ZDHHC4; AEBP1; CRYZ; KDM5C; ZMIZ1A; CNOT4B; ACE; PHF21A; CA3; ADAM5P

Interacting Protein

MTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA3.
HDAC1; HDAC2; MBD3; ESR1; AURKA; BCAR3; BAG4; TGFB1; IGF1R; PARP1