mta3
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  • Official Full Name
  • metastasis associated 1 family, member 3
  • Background
  • MTA1, MTA2, and MTA3 and 594 aa (MTA3L) proteins found in both the nucleus and the cytoplasmic compartments. It was identified as an Estrogen receptor (ER) regulated component of the Mi/NuRD histone deacetylase transcriptional repressor. In response to estrogen, MTA3 directly targets Snail, the master regulator of the epithelial to mesenchymal transition (EMT). Regulation of E-cadherin expression due to MTA3 and ER mediated signaling of Snail expression may be an important pathway in human breast tumors. Loss of ER results in decreased MTA3 expression and tamoxifen reduces expression of MTA3 in endometrial cells.
  • Synonyms
  • MTA3; metastasis associated 1 family, member 3; metastasis associated gene family, member 3; metastasis-associated protein MTA3; KIAA1266; metastasis associated family, member 3
Cat.#:MTA3-5682HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTA3 Protein, GST-tagged
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Cat.#:MTA3-1072HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTA3, GST-tagged
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Cat.#:MTA3-2891RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MTA3 Protein, His-tagged
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Cat.#:MTA3-10281ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTA3
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Cat.#:MTA3-4092HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTA3 293 Cell Lysate
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Involved Pathway

MTA3 involved in several pathways and played different roles in them. We selected most pathways MTA3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
KANSL3; ARID1A; SMARCA2; KAT7B; CHD4A; SAP30L; MTA3; MORF4L1; KAT8; KDM4A
Chromatin organization
SMYD2A; KDM4A; GATAD2B; ARID1A; ATF7IP; JMJD6; SMARCD3; ENY2; KDM4C; SUZ12
Gene Expression
ZNF433; ZNF71; ZNF114; TUBB3; CCNT2B; SMARCA5; ZNF286A; ZNF705A; ZNF311; HNRNPH1L
HDACs deacetylate histones
SAP18; HMG20B; KDM1A; GATAD2B; MBD3B; MBD3; MTA3; MTA1; GATAD2AB; ARID4A
RNA Polymerase I Promoter Clearance
MBD3A; TAF1D; CD3EAP; RRN3; MTA1; GATAD2A; TAF1C; MBD3B; TAF1A; MTA3
RNA Polymerase I Transcription
CD3EAP; RRN3; MBD3; MBD3B; TAF1B; TAF1D; TAF1C; CBX3A; MBD3A; EFCAB11
RNA Polymerase I Transcription Initiation
GATAD2AB; MTA3; CHD4; CHD4A; UBTF; MTA1; MTA2; GATAD2B; MBD3A; RRN3
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
SNAPC5; GTF3C5; SNAPC4; SNAPC3; SNAPC1B; GTF3C3; MBD3A; ZNF143B; CBX3; ZNF143

Protein Function

MTA3 has several biochemical functions, for example, chromatin binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA3 itself. We selected most functions MTA3 had, and list some proteins which have the same functions with MTA3. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein SIRT7; NCOA1; TADA2B; RELB; TLE1; HMGB2B; CCNT1; FEZF2; SMAD2; YBX2
Function protein binding
Related Protein KIF7; NUPL1; Reln; BNIP1; NELL1; C1S; CTNNB1; CXorf48; DNTT; PPP2CB
Function sequence-specific DNA binding
Related Protein NR4A2B; MAFBB; WT1; FOXI2; NR2E1; FOXG1D; NKX2.5; ZNF192; EF1; TBX3
Function transcription factor activity, sequence-specific DNA binding
Related Protein GTF2I; HMGA1B; PFDN1; NR1H5; ZNF691; ZNF192; ZNF74; ZFP367; NFE2; GTF3A
Function zinc ion binding
Related Protein TRIM35-23; MAN2B1; UQCRC2A; ADH5; PHC2; FTR67; ASH1L; MSL2B; TP53; TRIM35-29

Interacting Protein

MTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA3.
HDAC1; HDAC2; MBD3; ESR1; AURKA; BCAR3; BAG4; TGFB1; IGF1R; PARP1