Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

MTA3

Official Full Name

metastasis associated 1 family, member 3
Overview

MTA1, MTA2, and MTA3 and 594 aa (MTA3L) proteins found in both the nucleus and the cytoplasmic compartments. It was identified as an Estrogen receptor (ER) regulated component of the Mi/NuRD histone deacetylase transcriptional repressor. In response to estrogen, MTA3 directly targets Snail, the master regulator of the epithelial to mesenchymal transition (EMT). Regulation of E-cadherin expression due to MTA3 and ER mediated signaling of Snail expression may be an important pathway in human breast tumors. Loss of ER results in decreased MTA3 expression and tamoxifen reduces expression of MTA3 in endometrial cells.
Synonyms

MTA3; metastasis associated 1 family, member 3; metastasis associated gene family, member 3; metastasis-associated protein MTA3; KIAA1266; metastasis associated family, member 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
MYC
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MTA3-1072H	Recombinant Human MTA3, GST-tagged	E.coli	GST	1-343aa	$319 / 25ug
Human	MTA3-4092HCL	Recombinant Human MTA3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	MTA3-6480HF	Recombinant Full Length Human MTA3 Protein, GST-tagged	In Vitro Cell Free System	GST	515 amino acids	Inquiry
Human	MTA3-1228H	Recombinant Human MTA3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	MTA3-5682H	Recombinant Human MTA3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	Mta3-581M	Recombinant Mouse Mta3 Protein, MYC/DDK-tagged	HEK293T	MYC/DDK		Inquiry
Rhesus Macaque	MTA3-2891R	Recombinant Rhesus monkey MTA3 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	MTA3-2711R	Recombinant Rhesus Macaque MTA3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	MTA3-2711R-B	Recombinant Rhesus Macaque MTA3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MTA3-10281Z	Recombinant Zebrafish MTA3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

MTA3 involved in several pathways and played different roles in them. We selected most pathways MTA3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	PADI6;JMJD6;ZZZ3;RBBP4;EHMT2;ENY2;PHF20B;KDM3A;PHF2
Chromatin organization	GATAD2A;AEBP2;DR1;ING5A;ENY2;MBD3;ACTL6A;DNMT3A;MSL3
Gene Expression	NRBF2;ZNF26;ZNF71;TP53RK;TSEN54;HENMT1;A1CF;EHMT2;SET
HDACs deacetylate histones	SAP18;PHF21A;SAP30L;GATAD2A;ARID4A;HMG20B;GATAD2AB;CHD4;SUDS3
RNA Polymerase I Promoter Clearance	MBD3A;MBD3B;GATAD2B;TAF1C;MBD3;RRN3;UBTF;EFCAB11;GATAD2AB
RNA Polymerase I Transcription	CD3EAP;MTA2;MBD3;TAF1A;GATAD2A;MTA1;CHD4A;UBTF;MBD3B
RNA Polymerase I Transcription Initiation	GATAD2A;GATAD2AB;RRN3;UBTF;MTA2;MTA3;MBD3B;GATAD2B;MTA1
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	CHD4;RRN3;MTA3;PTRFB;GTF3AB;GTF3C4;MBD3;SNAPC3;BRF2

MTA3 has several biochemical functions, for example, chromatin binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTA3 itself. We selected most functions MTA3 had, and list some proteins which have the same functions with MTA3. You can find most of the proteins on our site.

Function	Related Protein
chromatin binding	SMARCA2;SMC3;L3MBTL1;OVOL2;SIRT2;HMGB3B;GATA1A;SKI;MNT
protein binding	SHANK3;ITGAX;RAPGEF6;MYO7B;GTF2F1;CD33;FBXO6;IGF2BP1;SCARB1
sequence-specific DNA binding	PAX7;HOXB7A;NANOGP8;FOXN1;VDRB;PBX3B;SP5;PPARAA;ELF2A
transcription factor activity, sequence-specific DNA binding	NPAS1;CEBPA;MESP1;E2F4;NR2F1B;CSRNP3;HOXA3A;NKX3;NTNG1
zinc ion binding	ZMYM4;ZFP330;DBF4;YY1;AFG3L2;DNPEP;DRL;ING3;MICALL2

MTA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTA3.

HDAC1; HDAC2; MBD3; ESR1; AURKA; BCAR3; BAG4; TGFB1; IGF1R; PARP1