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MTHFD2L

  • Official Full Name

    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like

  • Synonyms

    MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; MGC72244; MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; FLJ131;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTHFD2L-1083H Recombinant Human MTHFD2L, His-tagged E.coli His 1-146aa
Human MTHFD2L-1160HFL Recombinant Full Length Human MTHFD2L Protein, C-Flag-tagged Mammalian cells Flag
Human MTHFD2L-1453H-B Recombinant Human MTHFD2L Protein Pre-coupled Magnetic Beads HEK293
Human MTHFD2L-2188H Recombinant Human MTHFD2L Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MTHFD2L-5705H Recombinant Human MTHFD2L Protein, GST-tagged Wheat Germ GST
Human MTHFD2L-6710H Recombinant Human MTHFD2L Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MTHFD2L-6529HF Recombinant Full Length Human MTHFD2L Protein, GST-tagged In Vitro Cell Free System GST 146 amino acids
Human MTHFD2L-1453H Recombinant Human MTHFD2L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MTHFD2L-10193M Recombinant Mouse MTHFD2L Protein Mammalian Cell His
Mouse MTHFD2L-5780M Recombinant Mouse MTHFD2L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mthfd2l-4211M Recombinant Mouse Mthfd2l Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MTHFD2L-5780M-B Recombinant Mouse MTHFD2L Protein Pre-coupled Magnetic Beads HEK293
Rat MTHFD2L-3810R Recombinant Rat MTHFD2L Protein Mammalian Cell His
Rat MTHFD2L-3469R Recombinant Rat MTHFD2L Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MTHFD2L-3469R-B Recombinant Rat MTHFD2L Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MTHFD2L-10195Z Recombinant Zebrafish MTHFD2L Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MTHFD2L Related Articles

MTHFD2L involved in several pathways and played different roles in them. We selected most pathways MTHFD2L participated on our site, such as One carbon pool by folate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2L were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
One carbon pool by folateMTHFS;MTHFD1;MTR;ALDH1L1;ATIC;SHMT2;DHFRL1;MTHFD2;MTHFD2L
Metabolic pathwaysPLCH1;ACSS3;CHIA.2;CYP2P8;RDH8;ALG11;POLR3GLB;SDSL;B3GNT5

MTHFD2L has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2L itself. We selected most functions MTHFD2L had, and list some proteins which have the same functions with MTHFD2L. You can find most of the proteins on our site.

Function Related Protein
NOT formate-tetrahydrofolate ligase activityMTHFD2;MTHFD2L
methenyltetrahydrofolate cyclohydrolase activityMTHFD1;MTHFD2;MTHFD2L;MTHFD1B
methylenetetrahydrofolate dehydrogenase (NAD+) activityMTHFD1;MTHFD2;MTHFD2L
methylenetetrahydrofolate dehydrogenase (NADP+) activityMTHFD2;MTHFD2L;MTHFD1;MTHFD1B

MTHFD2L has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFD2L here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFD2L.

Marttinen, P; Pirinen, M; et al. Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. BIOINFORMATICS 30:2026-2034(2014).
Shin, M; Bryant, JD; et al. Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 289:15507-15517(2014).
Bolusani, S; Young, BA; et al. Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5166-5174(2011).
Appling, DR; et al. Enzymology of Mammalian Mitochondrial One-Carbon Metabolism. PTERIDINES 20:102-108(2009).
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