mthfd2l
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  • Official Full Name
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
  • Synonyms
  • MTHFD2L; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like; probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; MGC72244; MTHFD2-like; NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein; FLJ131
Cat.#:MTHFD2L-2188HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MTHFD2L Protein, MYC/DDK-tagged
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Cat.#:MTHFD2L-5705HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTHFD2L Protein, GST-tagged
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Cat.#:MTHFD2L-1083HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTHFD2L, His-tagged
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Cat.#:MTHFD2L-10193MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MTHFD2L Protein
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Cat.#:MTHFD2L-3810RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MTHFD2L Protein
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Cat.#:MTHFD2L-10195ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MTHFD2L
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Involved Pathway

MTHFD2L involved in several pathways and played different roles in them. We selected most pathways MTHFD2L participated on our site, such as One carbon pool by folate, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFD2L were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
One carbon pool by folate
MTHFD2; MTHFS; ALDH1L2; AMT; GART; MTHFR; MTHFD1; MTHFD1L; ST20-MTHFS; FTCD
Metabolic pathways
CMPK; ODC1; PYGM; PIGF; ALDOCB; INPP5KA; ACSM2B; AHCYL2; PTGESL; ACADM

Protein Function

MTHFD2L has several biochemical functions, for example, NOT formate-tetrahydrofolate ligase activity, methenyltetrahydrofolate cyclohydrolase activity, methylenetetrahydrofolate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFD2L itself. We selected most functions MTHFD2L had, and list some proteins which have the same functions with MTHFD2L. You can find most of the proteins on our site.
Function
Related Protein
Function NOT formate-tetrahydrofolate ligase activity
Related Protein MTHFD2L; MTHFD2
Function methenyltetrahydrofolate cyclohydrolase activity
Related Protein MTHFD2L; MTHFD2; MTHFD1B; MTHFD1
Function methylenetetrahydrofolate dehydrogenase (NAD+) activity
Related Protein MTHFD1; MTHFD2; MTHFD2L
Function methylenetetrahydrofolate dehydrogenase (NADP+) activity
Related Protein MTHFD2L; MTHFD1B; MTHFD2; MTHFD1

MTHFD2L Related Articles

Marttinen, P; Pirinen, M; et al. Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. BIOINFORMATICS 30:2026-2034(2014).
Shin, M; Bryant, JD; et al. Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 289:15507-15517(2014).
Bolusani, S; Young, BA; et al. Mammalian MTHFD2L Encodes a Mitochondrial Methylenetetrahydrofolate Dehydrogenase Isozyme Expressed in Adult Tissues. JOURNAL OF BIOLOGICAL CHEMISTRY 286:5166-5174(2011).
Appling, DR; et al. Enzymology of Mammalian Mitochondrial One-Carbon Metabolism. PTERIDINES 20:102-108(2009).