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MTHFS

  • Official Full Name

    5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

  • Overview

    The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms

    MTHFS; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; HsT19268; 10-methenyl-tetrahydrofolate synthetase; 5; 5 formyltetrahydrofolate cyclo ligase; 5,10 methenyl tetrahydrofolate synthetase; FLJ30410; Methenyl THF synthetase; Methenyl-THF synthetase; MTHFS_HUMAN; OTTHUMP00000185568;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTHFS-30253TH Recombinant Human MTHFS, His-tagged E.coli His 203 amino acids
Human MTHFS-3464H Recombinant Human MTHFS protein, His-tagged E.coli His
Human MTHFS-4080HCL Recombinant Human MTHFS 293 Cell Lysate HEK293 N/A
Human MTHFS-5706H Recombinant Human MTHFS Protein, GST-tagged Wheat Germ GST
Human MTHFS-01H Recombinant Human MTHFS Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human MTHFS-5880H Recombinant Human MTHFS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MTHFS-3914H Recombinant Human MTHFS Protein (Met1-Ala203), C-His tagged E.coli C-His Met1-Ala203
Human MTHFS-3252H Recombinant Human MTHFS protein, His-SUMO-tagged E.coli His-SUMO 2-203aa
Mouse MTHFS-10195M Recombinant Mouse MTHFS Protein Mammalian Cell His
Mouse MTHFS-5781M Recombinant Mouse MTHFS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MTHFS-5781M-B Recombinant Mouse MTHFS Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MTHFS-2899R Recombinant Rhesus monkey MTHFS Protein, His-tagged Mammalian Cell His
Rhesus Macaque MTHFS-2719R Recombinant Rhesus Macaque MTHFS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque MTHFS-2719R-B Recombinant Rhesus Macaque MTHFS Protein Pre-coupled Magnetic Beads HEK293
Chicken MTHFS-5005C Recombinant Chicken MTHFS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MTHFS involved in several pathways and played different roles in them. We selected most pathways MTHFS participated on our site, such as Metabolic pathways, One Carbon Metabolism, One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysKYNU;PLCB4;CYP2U1;CTH;PPOX;CERS2A;CYP2B6;ST8SIA1;CHKB
One Carbon MetabolismMTHFD2;FTCD;MTHFS;ALDH1L1;ST20-MTHFS;AHCY;MTFMT
One carbon pool by folateALDH1L1;AMT;MTHFR;ALDH1L2;MTR;DHFRL1;SHMT2;MTHFD1;ATIC

MTHFS has several biochemical functions, for example, 5-formyltetrahydrofolate cyclo-ligase activity, ATP binding, folic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFS itself. We selected most functions MTHFS had, and list some proteins which have the same functions with MTHFS. You can find most of the proteins on our site.

Function Related Protein
5-formyltetrahydrofolate cyclo-ligase activity
ATP bindingUBA2;WRNIP1;NADSYN1;MADD;DDX3Y;PI4KB;SLKA;PRKAG1;DHX57
folic acid bindingDMGDH;GNMT;TYMS;MTHFS;FOLR1;DAAM2;FOLR3;DHFR;SLC46A1
metal ion bindingCYP2P9;ATP13A3;DZIP1L;KCNIP3B;PRDM16;TRIM71;MBNL2;NEK9;ZBED6

MTHFS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFS here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFS.

TSC22D4

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