MTPN
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Official Full Name
myotrophin
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Overview
The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3 end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. -
Synonyms
MTPN; myotrophin; GCDP; granule cell differentiation protein; V 1; FLJ31098; FLJ99857; MTPN_HUMAN; Protein V 1; Protein V-1; V-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
MTPN involved in several pathways and played different roles in them. We selected most pathways MTPN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MTPN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
MTPN has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTPN itself. We selected most functions MTPN had, and list some proteins which have the same functions with MTPN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | DLX6;FOXC1A;NKX1.2LB;ZNF75D;MAF;EMX3;HOXA9;GRHL3;PPARAA |
MTPN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTPN here. Most of them are supplied by our site. Hope this information will be useful for your research of MTPN.
EPB41; HLA-B; VHL; IKBKE; DSTYK; TNFRSF10D; FTSJ1; PRKAB1; TRAF6; MAPK1; AKTIP; GABARAPL2
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