Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

MTR

Official Full Name

5-methyltetrahydrofolate-homocysteine methyltransferase
Overview

MTR encodes the enzyme 5-methyltetrahydrofolate-homocysteine methyltransferase. This enzyme, also known as cobalamin-dependent methionine synthase, catalyzes the final step in methionine biosynthesis. Mutations in MTR have been identified as the underlying cause of methylcobalamin deficiency complementation group G. [provided by RefSeq, Jul 2008]
Synonyms

MTR; 5-methyltetrahydrofolate-homocysteine methyltransferase; MS; HMAG; cblG; methionine synthase; cobalamin-dependent methionine synthase; vitamin-B12 dependent methionine synthase; 5-methyltetrahydrofolate-homocysteine methyltransferase 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Medicago tribuloides
Mouse
Mycobacterium Tuberculosis
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ
Yeast

Tag

GST
His
His (Fc)
Avi
Myc
His|SUMO|Myc
SUMO
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MTR-487H	Recombinant Human MTR Protein, His-tagged	E.coli	His	Ser923~Asp1265	$298 / 10ug
Human	MTR-5731H	Recombinant Human MTR Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MTR-301155H	Recombinant Human MTR protein, GST-tagged	E.coli	GST	Arg917-Asp1265	Inquiry
Human	MTR-1704H	Recombinant Human MTR Protein (923-1265 aa), His-tagged	Yeast	His	923-1265 aa	Inquiry
Human	MTR-4759H	Recombinant Human MTR protein, His-SUMO-tagged	E.coli	His-SUMO	923-1265aa	Inquiry
Mouse	Mtr-1799M	Recombinant Mouse Mtr Protein, His-tagged	E.coli	N-His	Ser911-Asp1253	Inquiry
Rat	MTR-3817R	Recombinant Rat MTR Protein	Mammalian Cell	His		Inquiry
Rat	MTR-3476R	Recombinant Rat MTR Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MTR-3476R-B	Recombinant Rat MTR Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Medicago tribuloides	MTR-1047M	Recombinant Medicago tribuloides MTR protein, His&Myc-tagged	E.coli	His&Myc	26-85aa	Inquiry
Mycobacterium Tuberculosis	MTR-2288M	Recombinant Mycobacterium Tuberculosis MTR Protein (1-459 aa), His-SUMO-Myc-tagged	E.coli	His/SUMO/Myc	1-459 aa	Inquiry
Zebrafish	MTR-9794Z	Recombinant Zebrafish MTR	Mammalian Cell	His		Inquiry
Chicken	MTR-2778C	Recombinant Chicken MTR	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MTR Related Articles

MTR involved in several pathways and played different roles in them. We selected most pathways MTR participated on our site, such as Cysteine and methionine metabolism, Selenocompound metabolism, One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cysteine and methionine metabolism	CBSB;MAT2AA;SDS;APIP;CBS;BCAT2;MAT1A;MPST;MAT2AB
Selenocompound metabolism	PAPSS2A;PAPSS2;SCLY;PAPSS2B;TXNRD2;CCBL2;INMT;SPS2;MARS2
One carbon pool by folate	TYMS;MTFMT;SHMT2;MTHFD1B;DHFRL1;MTHFS;GART;ALDH1L1;AMT
Metabolic pathways	GPI1;KL;NDUFA1;SAT1A.1;ST6GALNAC4;ALG14;HSD17B4;UCK2A;AHCYL2
Biosynthesis of amino acids	PRPS1A;MAT2B;PGAM1A;PKMB;PYCR1B;PFKMA;ALDOC;MAT1A;MAT2AL

MTR has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MTR itself. We selected most functions MTR had, and list some proteins which have the same functions with MTR. You can find most of the proteins on our site.

Function	Related Protein

MTR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTR.

Colombo, GL; Castagna, A; et al. Cost analysis of initial highly active antiretroviral therapy regimens for managing human immunodeficiency virus-infected patients according to clinical practice in a hospital setting. THERAPEUTICS AND CLINICAL RISK MANAGEMENT 10:9-15(2014).

Gueant, JL; Caillerez-Fofou, M; et al. Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase. BIOCHIMIE 95:1033-1040(2013).