Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

MTRR

  • Official Full Name

    5-methyltetrahydrofolate-homocysteine methyltransferase reductase

  • Overview

    Methionine is an essential amino acid required for protein synthesis and one-carbon metabolism. Its synthesis is catalyzed by the enzyme methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. The protein encoded by this gene regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. Patients of the cbl-E complementation group of disorders of folate/cobalamin metabolism are defective in reductive activation of methionine synthase. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
  • Synonyms

    MTRR; 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; methionine synthase reductase; cblE; [methionine synthase] cobalamin methyltransferase (cob(II)alamin reducing); 5 methyltetrahydrofolate homocysteine methyltransferase reductase; Methionine synthase reductase, mitochondrial; MGC129643; MSR; OTTHUMP00000115546; OTTHUMP00000220821; [methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing);

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MTRR-4065HCL Recombinant Human MTRR 293 Cell Lysate HEK293 N/A
Human MTRR-1725H Recombinant Human MTRR Protein (1-725 aa), His-tagged Yeast His 1-725 aa
Human MTRR-5735H Recombinant Human MTRR Protein, GST-tagged Wheat Germ GST
Human MTRR-1153H Recombinant Human MTRR Protein (1-725 aa), GST-tagged E.coli GST 1-725 aa
Mouse MTRR-10220M Recombinant Mouse MTRR Protein Mammalian Cell His
Mouse MTRR-5797M Recombinant Mouse MTRR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mtrr-1800M Recombinant Mouse Mtrr Protein, His-tagged E.coli N-His Asp269-Pro531
Mouse MTRR-5797M-B Recombinant Mouse MTRR Protein Pre-coupled Magnetic Beads HEK293
Rat MTRR-3819R Recombinant Rat MTRR Protein Mammalian Cell His
Rat MTRR-3478R Recombinant Rat MTRR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mtrr-1801R Recombinant Rat Mtrr Protein, His-tagged E.coli N-His Asp272-Pro534
Rat MTRR-3478R-B Recombinant Rat MTRR Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

MTRR involved in several pathways and played different roles in them. We selected most pathways MTRR participated on our site, such as Biological oxidations, Cobalamin (Cbl, vitamin B12) transport and metabolism, Defective MTR causes methylmalonic aciduria and homocystinuria type cblG, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTRR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Biological oxidationsSULT1ST5;CYP2K22;CYP2Y3;PRKRA;CYP3C1;UGT1B1;Sult2a2;SULT1C2;CYP2C9
Cobalamin (Cbl, vitamin B12) transport and metabolismCTRC;MTRR;CD320;AMN;ELA2;MMADHC;LOC100686744;CTRB1;CBLC-1
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
Defects in cobalamin (B12) metabolismMMAA;AMN;MTRR;MMADHC
Defects in vitamin and cofactor metabolismMMADHC;MTRR;MMAA;AMN
DiseaseCHMP4C;JAG1;AP2B1;OPN1LW;GPC5;CTBP2;TLR10;HEY2;EPM2A
Diseases of metabolismSFTPC;CYP11A1;MMAA;AMN;CCDC59;GYG1;FDXR;MMADHC;FDX1

MTRR has several biochemical functions, for example, FAD binding, FMN binding, NADP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTRR itself. We selected most functions MTRR had, and list some proteins which have the same functions with MTRR. You can find most of the proteins on our site.

Function Related Protein
FAD bindingCYB5R3;COQ6;DAO;DAO1;DDO;MICAL2B;AGPS;MTRR;PRODH
FMN bindingNOS1;NOS3;NOS2;MTRR;HAO2;TYW1;CREG1;NOS2B;HAO1
NADP bindingMTHFR;NOX1;NOX5;H6PD;CAT;DPYD;FMO5;MIOX;MTRR
NADPH bindingDHFR;CRYZ;MTRR;KCNAB1;GRHPR;FASN;DECR1;CBR3;QDPR
NADPH-hemoprotein reductase activityPOR;NOS2A;CYP2J6;NDOR1;NOS2B;MTRR;NOS2;NOS3;NOS1
[methionine synthase] reductase activity
aquacobalamin reductase (NADPH) activity
flavin adenine dinucleotide bindingCHDH;NOS3;PPOX;FMO1;FOXRED2;TXNRD2;MTHFR;ACADL;CYBB
iron ion bindingCH25HL2;CYP2D26;CYP46A1.1;HBG2;CYP2C19;TPH1;CYP2X7;ALOX12;CYP4F11
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenCOQ6;CYP4F11;CYP11A1;CYP11B2;CYP4F18;NDOR1;MTRR;MICAL1;POR
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
protein bindingMESDC1;MTRR;RPS18;LGI4;RTN4R;ZYX;LYRM2;USP1;LGALS2

MTRR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTRR here. Most of them are supplied by our site. Hope this information will be useful for your research of MTRR.

FLJ13057

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All MTRR Products

Required fields are marked with *

My Review for All MTRR Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends