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MUC4

Official Full Name

mucin 4, cell surface associated
Overview

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
Synonyms

MUC4; mucin 4, cell surface associated; ASGP; MUC-4; HSA276359; mucin-4; testis mucin; tracheobronchial mucin; ascites sialoglycoprotein; mucin 4, tracheobronchial; pancreatic adenocarcinoma mucin;

Type

Recombinant Proteins

Species

Human
Rat
Rattus norvegicus (Rat)

Source

Baculovirus-Insect cells
E.coli
E.coli expression system
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MUC4-5763H	Recombinant Human MUC4 protein, His-tagged	E.coli	His	Pro1154~Glu1309 (Accession # Q99102)	Inquiry
Human	MUC4-112H	Recombinant Human MUC4 protein, GST-tagged	Wheat Germ	N/A		Inquiry
Human	MUC4-5750H	Recombinant Human MUC4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	MUC4-4627H	Recombinant Human MUC4 Protein (Glu1875-Phe1914), N-GST tagged	E.coli	N-GST	Glu1875-Phe1914	Inquiry
Human	MUC4-0215H	Recombinant Human MUC4 Protein (Gly1869-Asn1925), C-His-tagged	Baculovirus-Insect cells	C-His	Gly1869-Asn1925	Inquiry
Human	MUC4-4628H	Recombinant Human MUC4 Protein (Val2078-Glu2117), N-GST tagged	E.coli	N-GST	Val2078-Glu2117	Inquiry
Rat	Muc4-1805R	Recombinant Rat Muc4 Protein, His-tagged	E.coli	N-His	Pro1141-Pro1316	Inquiry
Rattus norvegicus (Rat)	RFL1262RF	Recombinant Full Length Rat Mucin-4(Muc4) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (1616-2344)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
MUC4 Related Articles
MUC4 Related Research Area

MUC4 involved in several pathways and played different roles in them. We selected most pathways MUC4 participated on our site, such as Metabolism of proteins, O-linked glycosylation, O-linked glycosylation of mucins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MUC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Metabolism of proteins	SEC16B;TIMM50;KLK13;ADAMTSL5;KLHDC3;TOMM20;TIMM10;UBA2;ARSI
O-linked glycosylation	SPON1B;B3GNT8;THSD1;GALNT13;MUC12;B3GNT2A;ADAMTS5;GALNTL5;ADAMTS13
O-linked glycosylation of mucins	GALNT13;KCNA6;MUC1;GALNTL2;GALNT6;MUC4;MUC13;MUC5AC;GCNT3
Post-translational protein modification	MIA3;SEC16B;TFG;ADAMTS13;SMC5;PPP6R1;NAPB;TRAPPC3;SENP1
Termination of O-glycan biosynthesis	MUC1;MUC5AC;MUC21;MUC15;MUC12;MUC20;MUC4;MUCL1;MUC13

MUC4 has several biochemical functions, for example, ErbB-2 class receptor binding, extracellular matrix constituent, lubricant activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MUC4 itself. We selected most functions MUC4 had, and list some proteins which have the same functions with MUC4. You can find most of the proteins on our site.

Function	Related Protein
ErbB-2 class receptor binding	MUC4;CDK5;NRG1
extracellular matrix constituent, lubricant activity	STATH;MUC4

MUC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUC4.

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Decouvelaere, AV; et al. Immunohistochemistry in the diagnosis of sarcomas. ANNALES DE PATHOLOGIE 35:98-106(2015).

Elster, N; Collins, DM; et al. HER2-family signalling mechanisms, clinical implications and targeting in breast cancer. BREAST CANCER RESEARCH AND TREATMENT 149:5-15(2015).

Pancreatic Cancer Biomarkers

Epithelial Cell Markers and Intracellular Molecules

Apical Molecules