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MUM1

Official Full Name

melanoma associated antigen (mutated) 1
Overview

The MUM1 (Multiple Myeloma Oncogene 1) gene was originally identified because of its involvement in the t(6;14) translocation observed in multiple myeloma, which causes juxtaposition of the MUM1 gene to the lg heavy-chain locus. MUM1 is expressed in a wide spectrum of lymphoid neoplasms but not in myeloid and extra-hematopoitic tumors. MUM1 is a valuable marker for understanding and characterizing histogenensis of B-cell lymphomas. It is an excellent marker for Hodgkin's and Reed-Sternberg cells of classic Hodgkin's disease in combination with CD30.
Synonyms

MUM1; melanoma associated antigen (mutated) 1; PWWP domain-containing protein MUM1; MUM 1; protein expandere; melanoma ubiquitous mutated protein; mutated melanoma-associated antigen 1; MUM-1; EXPAND1; HSPC211; FLJ14868; FLJ22283; MGC131891; MGC163315;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MUM1-1112H	Recombinant Human MUM1, GST-tagged	E.coli	GST	1-152aa	$319 / 25ug
Human	MUM1-1156HCL	Recombinant Human MUM1 cell lysate		N/A		Inquiry
Human	MUM1-3191H	Recombinant Human MUM1 protein, His-tagged	E.coli	His	1-152 aa	$319 / 25ug
Mouse	MUM1-10238M	Recombinant Mouse MUM1 Protein	Mammalian Cell	His		Inquiry
Mouse	MUM1-5807M-B	Recombinant Mouse MUM1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MUM1-5807M	Recombinant Mouse MUM1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	MUM1-5444C	Recombinant Chicken MUM1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MUM1 Related Articles
MUM1 Related Research Area

MUM1 involved in several pathways and played different roles in them. We selected most pathways MUM1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MUM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MUM1 has several biochemical functions, for example, nucleosome binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MUM1 itself. We selected most functions MUM1 had, and list some proteins which have the same functions with MUM1. You can find most of the proteins on our site.

Function	Related Protein
nucleosome binding	NOC2L;ZNHIT1;RNF168;DNTTIP1;SMARCA5;MUM1;RNF4;L3MBTL1;HP1BP3
protein binding	PITX2;ULK3;MTA3;PPFIA4;EEF1E1;TFAM;TLE2;EVLA;MC4R

MUM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MUM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MUM1.

SMC6

Treetipsatit, J; Rimzsa, L; et al. Variable Expression of B-cell Transcription Factors in Reactive Immunoblastic Proliferations A Potential Mimic of Classical Hodgkin Lymphoma. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1655-1663(2014).

Guo, Y; Takeuchi, I; et al. Array-comparative genomic hybridization profiling of immunohistochemical subgroups of diffuse large B-cell lymphoma shows distinct genomic alterations. CANCER SCIENCE 105:481-489(2014).

Tumor Antigens